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Can poor nutrition and diet influence temporomandibular disorder? A systematic review.

  • 2026-06-23
  • BMC oral health 26(1)
    • Flávio Fidêncio de Lima
    • Artin Razavian
    • Mai Hosokawa
    • Tatiana Ferreira Foscaldo
    • Melisa Koldzo
    • Rodrigo Lorenzi Poluha
    • Maria Christidis
    • Nikolaos Christidis
    • Giancarlo De la Torre Canales

Study Design

Type
Systematic Review
Methods
An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to November 2025. Risk of bias was performed using the Study Quality Assessment Tools from the National Heart, Lung, and Blood Institute (NHLBI).

Background

The relationship between diet, nutrition, and painful temporomandibular disorders (TMD) is not well established, despite increasing interest in lifestyle factors in chronic pain. This systematic review aimed to synthesize available evidence on how dietary patterns and nutritional status may be associated with painful TMD.

Methods

An electronic search was conducted in the databases MEDLINE, CINAHL, EMBASE, the Cochrane Central Registry of Controlled Trials (CENTRAL) and Web of Science for clinical and observational trials from the beginning of each database to November 2025. Risk of bias was performed using the Study Quality Assessment Tools from the National Heart, Lung, and Blood Institute (NHLBI).

Results

Out of 7,760 records and after the risk of bias assessment, only seven studies judged as having a low risk of bias were included. Overall, the included studies indicate that the association between dietary factors and TMD remains unclear. Prospective cohort studies did not demonstrate that prenatal or adolescent diet quality independently predicted TMD. Cross-sectional studies suggested that specific dietary patterns may be related to TMD-related symptoms. Women with myogenous TMD showed lower intake of several nutrients compared with controls. Experimental evidence indicated that monosodium glutamate ingestion increased pain intensity in myofascial TMD, while the only randomized trial found no significant pain differences between vitamin D supplementation and diclofenac.

Conclusions

Current evidence suggests that some dietary components and nutritional factors may be associated with TMD-related symptoms or pain responses; however, the findings are limited, heterogeneous, and insufficient to support firm causal or therapeutic conclusions.

Research Insights

  • Vitamin D→Reduced Pain Intensity

    the only randomized trial found no significant pain differences between vitamin D supplementation and diclofenac

    Effect
    Neutral
    Effect size
    Small
    Dose
    not specified
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