Effect of NSAIDs, melatonin, vitamin D and vitamin B12 chronotherapy on postoperative recovery after third molar surgical extraction: A pilot randomized crossover placebo-controlled trial.
- 2026-06-03
- RCT
- Oral and maxillofacial surgery 30(1)
- Mohammad Abusamak
- Fabián Pérez-González
- Leire Virto Ruiz
- Luis Miguel Sáez-Alcaide
- Haider Al-Waeli
- Jesus Torres García-Denche
- Faleh Ahmad Tamimi Marino
- PubMed: 42230417
- DOI: 10.1007/s10006-026-01582-0
- High evidence
Female participants reported statistically higher, although clinically insignificant, postoperative pain scores with chronotherapy (mean VAS increase: +0.94 points, p < 0.001)
- Effect
- Harmful
- Effect size
- Small
- Significant
- Yes
- Dose
- 1000 µg