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Abstract

Background: Lactic acid bacteria (LAB) have been demonstrated to have cholesterol-reducing effects in many studies.

Results: Lactobacillus fermentum SM-7 screened from ten LAB strains isolated from koumiss, a fermented milk drink, reduced cholesterol by 66.8%. It also showed acid and bile tolerance as well as antimicrobial activity against pathogenic Escherchia coli and Staphylococcus aureus. Lactobacillus fermentum SM-7 cells assimilated 61.5% and co-precipitated and absorbed 38.5% of the cholesterol in the media. Co-precipitation of cholesterol with cholic acid increased rapidly at pH levels below 6. In vivo experiments using L. fermentum SM-7 on artificially induced hyperlipidaemial ICR mice significantly decreased serum total cholesterol and total triglyceride levels, low-density lipoprotein cholesterol concentrations and atherogenic index (P < 0.01), while serum high-density lipoprotein cholesterol concentrations did not increase significantly (P > 0.05). The body weight and liver weight/body weight ratio of SM-7 groups were lower than those of mice on a high-cholesterol diet that were not given lactobacilli. There was no bacterial translocation in the liver, spleen or kidney of experimental mice.

Conclusion: The results suggested that L. fermentum SM-7 is a potential probiotic bacterium with cholesterol-lowering effects.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus fermentumIncreased HDL Cholesterol LevelsNeutral
Small
Lactobacillus fermentumReduced Atherogenic IndexBeneficial
Large
Lactobacillus fermentumReduced Bacterial TranslocationNeutral
Large
Lactobacillus fermentumReduced Body WeightBeneficial
Moderate
Lactobacillus fermentumReduced Low-Density Lipoprotein LevelBeneficial
Large
Lactobacillus fermentumReduced Serum Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum HA-179Improved Lipid ProfileBeneficial
Large
Lactobacillus fermentum HA-179Improved Weight ManagementBeneficial
Moderate
Lactobacillus fermentum HA-179Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum Lf-33Increased HDL Cholesterol LevelsNeutral
Small
Lactobacillus fermentum Lf-33Reduced Bacterial TranslocationNeutral
Large
Lactobacillus fermentum Lf-33Reduced Body WeightBeneficial
Moderate
Lactobacillus fermentum Lf-33Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced Atherogenic IndexBeneficial
Large
Lactobacillus fermentum LF61Reduced Body WeightBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Liver Weight-to-Body Weight RatioBeneficial
Moderate
Lactobacillus fermentum LF61Reduced Low-Density Lipoprotein CholesterolBeneficial
Large
Lactobacillus fermentum LF61Reduced Serum Total CholesterolBeneficial
Large
Lactobacillus fermentum LF61Reduced Serum Total Triglyceride LevelsBeneficial
Large
Lactobacillus fermentum LF61Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum LF61Stable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Lactobacillus fermentum MAK20L13FImproved Lipid ProfileBeneficial
Large
Lactobacillus fermentum MAK20L13FMaintained High-Density Lipoprotein LevelsNeutral
Small
Lactobacillus fermentum MAK20L13FReduced Bacterial TranslocationNeutral
Large
Lactobacillus fermentum MAK20L13FReduced Body WeightBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Pathogen ActivityBeneficial
Moderate
Lactobacillus fermentum MAK20L13FReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum ME-3Enhanced Antimicrobial ResistanceBeneficial
Moderate
Lactobacillus fermentum ME-3Improved Lipid ProfileBeneficial
Large
Lactobacillus fermentum ME-3Improved Weight ManagementBeneficial
Moderate
Lactobacillus fermentum ME-3Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum UALf-32Improved Lipid ProfileBeneficial
Large
Lactobacillus fermentum UALf-32Reduced Bacterial TranslocationNeutral
Large
Lactobacillus fermentum UALf-32Reduced Body WeightBeneficial
Moderate
Lactobacillus fermentum UALf-32Reduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus fermentum VPro 14Reduced Atherogenic IndexBeneficial
Large
Lactobacillus fermentum VPro 14Reduced LDL CholesterolBeneficial
Large
Lactobacillus fermentum VPro 14Reduced Serum Total Triglyceride LevelsBeneficial
Large
Lactobacillus fermentum VPro 14Reduced Total Cholesterol LevelsBeneficial
Large

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