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Clinical and radiological assessment of grape seed extract versus mineral trioxide aggregates in primary molar pulpotomy: A randomized controlled clinical trial.

  • 2025-09-26
  • Medicine 104(39)
    • Noura Mohammed Bakr
    • Gihan Adel Balbola
    • Soha Fuad Alqadi
    • Najla Dar-Odeh
    • Shadia Elsayed
    • Nuha Alghamdi
    • Nisreen Nabiel Hassan
    • Sara N Hashem
    • Safaa Ramadan El Sayed

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 32
Population
32 primary teeth
Methods
prospective split-mouth randomized clinical study; MTA used in group I, GSE used in group II
Duration
6 months

Background

This study aimed to assess the radiological and clinical outcomes of mineral trioxide aggregates (MTA) versus grape seed extract (GSE) when used as a dressing material in primary teeth undergoing pulpotomy.

Methods

This was a prospective split-mouth randomized clinical study. A total of 32 primary teeth were included and split into 2 groups: MTA was used in group I, and GSE was used in group II. A clinical and radiographic follow-up was conducted for 6 months postoperatively. Periapical radiographs were taken for all treated teeth at 3- and 6-month follow-up visits. Radiographic criteria for clinical success included absence of internal resorption, pathologic external resorption, interradicular radiolucency, periapical radiolucency, and widening of the periodontal ligament space.

Result

In the MTA group, clinical and radiographic success was 100% at 1 and 3 months, in comparison to 93.75% 6 months postoperatively. In the GSE group, clinical success was 100% 1 month, and 93.75% 3 and 6 months postoperatively, while radiographic success was 100% at 3 months, 87.5% 6 months postoperatively. There were no significant statistical differences in the overall clinical or radiographic outcomes between the study groups (P > .05).

Conclusion

Both MTA and GSE are associated with successful clinical and radiographic outcomes of pulpotomy; however, MTA seems to be associated with reduced inflammatory reactions, rendering it more effective than GSE.

Research Insights

  • Red Grape→Improved Clinical Success

    In the GSE group, clinical success was 100% 1 month, and 93.75% 3 and 6 months postoperatively. There were no significant statistical differences in the overall clinical or radiographic outcomes between the study groups (P > .05).

    Effect
    Neutral
    Effect size
    Small
  • Red Grape→Improved Radiographic Success

    radiographic success was 100% at 3 months, 87.5% 6 months postoperatively. There were no significant statistical differences in the overall clinical or radiographic outcomes between the study groups (P > .05).

    Effect
    Neutral
    Effect size
    Small
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