Clinical efficacy of grape seed extract as an adjuvant to scaling and root planing in treatment of periodontal pockets.

2021-04-30
Journal of biological regulators and homeostatic agents 35(2_Suppl_1)
- M Das
- A C Das
- S Panda
- A Greco Lucchina
- R Mohanty
- B Manfredi
- M Rovati
- M S Giacomello
- L Colletti
- C Mortellaro
- A Satpathy
- M Del Fabbro

PubMed: 34281305
DOI: 10.23812/21-2supp1-8

Study Design

Type: Randomized Controlled Trial (RCT)
Sample size: n = 64
Population: 72 patients (mean age 39.2±8.6 years) with periodontal pockets
Methods: Longitudinal, parallel design, randomized clinical trial; test group received intra-pocket delivery of GSE with SRP, control group received SRP alone
Duration: 3 months
Funding: Unclear

Grape seed extract (GSE), a naturally producing polyphenolic compound, is found to be a potent hostmodulatory agent and considered for management of periodontal disease. Its anti-bacterial, antioxidant, and anti-inflammatory property may aid in achieving periodontal health. To assess the clinical efficacy of GSE in adjunct to scaling and root planing (SRP) in healing of periodontal pockets. The present study was a longitudinal, parallel design, randomized clinical trial. Seventy-two patients (mean age 39.2±8.6 years) with periodontal pockets were randomly divided into two groups; Test group received intra-pocket delivery of GSE with SRP and Control group received SRP alone. The clinical parameters like Plaque Index (PI), Gingival Index (GI), Probing Depth (PD) and Relative Attachment Level (RAL) were recorded at baseline and 3 months. 64 patients completed the study. Test group at the end of 3 months had statistically significant reduced PD (p=0.002) and RAL (p=0.01). No significant difference was observed for PI and GI at the end of 3 months. Intra-pocket application of GSE with SRP could be beneficial in management of periodontal pockets.

Research Insights

Red Grape→Reduced Gingival Index
No significant difference was observed for PI and GI at the end of 3 months.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Plaque Index
No significant difference was observed for PI and GI at the end of 3 months.
Effect
Neutral
Effect size
Small
Red Grape→Reduced Probing Depth
Test group at the end of 3 months had statistically significant reduced PD (p=0.002)
Effect
Beneficial
Effect size
Small
Red Grape→Reduced Relative Attachment Level
Test group at the end of 3 months had statistically significant reduced ... RAL (p=0.01)
Effect
Beneficial
Effect size
Small