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Abstract

Aim: To assess the symptomatic efficacy of Lactobacillus plantarum 299v (L. plantarum 299v) (DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome (IBS) patients fulfilling the Rome III criteria.

Methods: In this double blind, placebo-controlled, parallel-designed study, subjects were randomized to daily receive either one capsule of L. plantarum 299v (DSM 9843) or placebo for 4 wk. Frequency and intensity of abdominal pain, bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.

Results: Two hundred and fourteen IBS patients were recruited. After 4 wk, both pain severity (0.68 + 0.53 vs 0.92 + 0.57, P < 0.05) and daily frequency (1.01 + 0.77 vs 1.71 + 0.93, P < 0.05) were lower with L. plantarum 299v (DSM 9843) than with placebo. Similar results were obtained for bloating. At week 4, 78.1 % of the patients scored the L. plantarum 299v (DSM 9843) symptomatic effect as excellent or good vs only 8.1 % for placebo (P < 0.01).

Conclusion: A 4-wk treatment with L. plantarum 299v (DSM 9843) provided effective symptom relief, particularly of abdominal pain and bloating, in IBS patients fulfilling the Rome III criteria.

Keywords: Abdominal pain; Clinical trial; Irritable bowel syndrome; Lactobacillus plantarum 299v; Probiotics.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarumImproved Symptom ReliefBeneficial
Large
Lactobacillus plantarumReduced Abdominal Pain FrequencyBeneficial
Moderate
Lactobacillus plantarumReduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarumReduced BloatingBeneficial
Moderate
Lactobacillus plantarum 299vImproved General IBS SymptomsBeneficial
Large
Lactobacillus plantarum 299vReduced Abdominal Pain FrequencyBeneficial
Moderate
Lactobacillus plantarum 299vReduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarum 299vReduced BloatingBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Overall Symptom ReliefBeneficial
Large
Lactobacillus plantarum DSM 6595Reduced Abdominal Pain FrequencyBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarum DSM 6595Reduced BloatingBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Abdominal Pain FrequencyBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced BloatingBeneficial
Moderate
Lactobacillus plantarum DSM 6596Relieved Intestinal ImpairmentsBeneficial
Large
Lactobacillus plantarum HA-119Improved Abdominal Pain FrequencyBeneficial
Moderate
Lactobacillus plantarum HA-119Improved Symptom ReliefBeneficial
Large
Lactobacillus plantarum HA-119Reduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Bloating SeverityBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Abdominal PainBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Irritable Bowel Syndrome SymptomsBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Patient SatisfactionBeneficial
Large
Lactobacillus plantarum UALp-05MReduced Abdominal Pain SeverityBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced BloatingBeneficial
Moderate

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