Clinical trial: Lactobacillus plantarum 299v (DSM 9843) improves symptoms of irritable bowel syndrome.
- 2012
- World Journal of Gastroenterology 18(30)
- P. Ducrotte
- P. Sawant
- V. Jayanthi
- PubMed: 22912552
- DOI: 10.3748/wjg.v18.i30.4012
Abstract
Aim: To assess the symptomatic efficacy of Lactobacillus plantarum 299v (L. plantarum 299v) (DSM 9843) for the relief of abdominal symptoms in a large subset of irritable bowel syndrome (IBS) patients fulfilling the Rome III criteria.
Methods: In this double blind, placebo-controlled, parallel-designed study, subjects were randomized to daily receive either one capsule of L. plantarum 299v (DSM 9843) or placebo for 4 wk. Frequency and intensity of abdominal pain, bloating and feeling of incomplete rectal emptying were assessed weekly on a visual analogue scale while stool frequency was calculated.
Results: Two hundred and fourteen IBS patients were recruited. After 4 wk, both pain severity (0.68 + 0.53 vs 0.92 + 0.57, P < 0.05) and daily frequency (1.01 + 0.77 vs 1.71 + 0.93, P < 0.05) were lower with L. plantarum 299v (DSM 9843) than with placebo. Similar results were obtained for bloating. At week 4, 78.1 % of the patients scored the L. plantarum 299v (DSM 9843) symptomatic effect as excellent or good vs only 8.1 % for placebo (P < 0.01).
Conclusion: A 4-wk treatment with L. plantarum 299v (DSM 9843) provided effective symptom relief, particularly of abdominal pain and bloating, in IBS patients fulfilling the Rome III criteria.
Keywords: Abdominal pain; Clinical trial; Irritable bowel syndrome; Lactobacillus plantarum 299v; Probiotics.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus plantarum | Improved Symptom Relief | Beneficial | Large |
| Lactobacillus plantarum | Reduced Abdominal Pain Frequency | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Bloating | Beneficial | Moderate |
| Lactobacillus plantarum 299v | Improved General IBS Symptoms | Beneficial | Large |
| Lactobacillus plantarum 299v | Reduced Abdominal Pain Frequency | Beneficial | Moderate |
| Lactobacillus plantarum 299v | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum 299v | Reduced Bloating | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Improved Overall Symptom Relief | Beneficial | Large |
| Lactobacillus plantarum DSM 6595 | Reduced Abdominal Pain Frequency | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6595 | Reduced Bloating | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Abdominal Pain Frequency | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Reduced Bloating | Beneficial | Moderate |
| Lactobacillus plantarum DSM 6596 | Relieved Intestinal Impairments | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Improved Abdominal Pain Frequency | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Improved Symptom Relief | Beneficial | Large |
| Lactobacillus plantarum HA-119 | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Reduced Bloating Severity | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Abdominal Pain | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Improved Irritable Bowel Syndrome Symptoms | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Improved Patient Satisfaction | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Reduced Abdominal Pain Severity | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Reduced Bloating | Beneficial | Moderate |