Clostridioides difficile Infections: Prevention and Treatment Strategies.
- 2024-01-01
- Advances in experimental medicine and biology 1449
- Elvira Ingrid Levy
- Meltem Dinleyici
- Ener Dinleyici
- Yvan Vandenplas
- PubMed: 39060738
- DOI: 10.1007/978-3-031-58572-2_11
Study Design
- Type
- Review
Clostridioides difficile is the most common causative agent of antibiotic-associated diarrhea. This spore forming, obligate anaerobic, gram-positive bacillus is becoming responsible for an increasing number of infections worldwide, both in community and in hospital settings, whose severity can vary widely from an asymptomatic infection to a lethal disease. While discontinuation of antimicrobial agents and antibiotic treatment of the infection remain the cornerstone of therapy, more recent fecal microbiota transplantation has also been valid as a therapy. The use of probiotics, especially Saccharomyces boulardii CNCM I-745 have become valid forms of prevention therapy. Although there are studies in adults with microbiota-targeted new generation therapies and Clostridium difficile vaccines, there are no data in the paediatric age group yet.
Research Insights
The use of probiotics, especially Saccharomyces boulardii CNCM I-745 have become valid forms of prevention therapy.
- Effect
- Beneficial
- Effect size
- Small