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Coffee and tea consumption on the risk of osteoporosis: a meta-analysis.

  • 2025-03-04
  • Frontiers in nutrition 12
    • Wopei Li
    • Yujiao Xie
    • Lei Jiang

Study Design

Type
Systematic Review
Sample size
n = 838
Population
562,838 participants from 14 observational studies
Methods
Systematic search and meta-analysis of observational studies using Stata software; fixed-effects and random-effects models

Objectives

This meta-analysis aims to quantify the relationship between coffee and tea consumption and the risk of osteoporosis and explore whether such consumption positively or negatively impacts this risk, thereby providing a scientific basis for understanding the effects of coffee and tea on bone health.

Methods

We systematically searched PubMed, the Cochrane Library, and Embase for observational studies published up to November 5, 2024, using medical subject headings (MeSH) and keywords related to "osteoporosis, tea, and coffee." Statistical analyses were conducted using Stata software version 14.0. A fixed-effects model was used when heterogeneity was low (I2 ≤ 50% and p > 0.1). A random-effects model was used for greater heterogeneity (I2 > 50%). Publication bias was assessed using funnel plots and Egger's regression tests.

Results

This meta-analysis included 14 observational studies comprising 562,838 participants published between 2008 and 2024. The pooled analysis showed that coffee consumption is significantly associated with a reduced risk of osteoporosis (odds ratio [OR] = 0.79, 95% confidence interval I2 = 28.9%, p < 0.05). Tea consumption also demonstrated a protective effect, with a lower risk of osteoporosis (OR = 0.75, 95% CI: 0.62-0.91, I2 = 80.4%, p < 0.05). Subgroup analysis revealed that high-frequency coffee consumption (more than one cup per day) was associated with a greater reduction in osteoporosis risk (OR = 0.83, 95% CI: 0.74-0.93, p = 0.001) compared to low-frequency consumption (less than one cup per day), which showed no statistically significant reduction (OR = 0.86, 95% CI: 0.68-1.07, p = 0.171). Similarly, high-frequency tea consumption (more than four times per week) exhibited a slightly stronger protective effect against osteoporosis compared to low-frequency consumption (OR = 0.82, 95% CI: 0.70-0.97, p = 0.02).

Conclusion

This meta-analysis suggests that long-term coffee and tea consumption is associated with a reduced risk of osteoporosis. Moreover, a higher frequency of consumption within a moderate range appeared to enhance the protective effect against osteoporosis.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42024612101, PROSPERO CRD42024612101.

Research Insights

  • Coffee→Reduced Osteoporosis Risk

    Subgroup analysis revealed that high-frequency coffee consumption (more than one cup per day) was associated with a greater reduction in osteoporosis risk (OR = 0.83, 95% CI: 0.74-0.93, p = 0.001) compared to low-frequency consumption.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    more than one cup per day (high-frequency)
  • Tea→Reduced Osteoporosis Risk

    Subgroup analysis revealed that high-frequency coffee consumption (more than one cup per day) was associated with a greater reduction in osteoporosis risk (OR = 0.83, 95% CI: 0.74-0.93, p = 0.001) compared to low-frequency consumption.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    more than one cup per day (high-frequency)
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