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Comparison of the Effects of Dill Seed, Grape Seed and Date Extracts on Postpartum Hemorrhage Rates in the Fourth Stage of Labor: A Randomized Clinical Trial.

  • 2025-01
  • Reviews on recent clinical trials 20(1)
    • Arezoo Shayan
    • Mansoureh Refaei
    • Hamideh Parsapour
    • Seyedeh Zahra Masoumi
    • Hassan Ahmadinia
    • Shirin Moradkhani
    • Mahtab Sattari
    • Minoo Hamoun

Study Design

Type
Randomized Controlled Trial (RCT)
Population
200 multiparous women in the fourth stage of labor
Methods
Double-blind parallel-group RCT, four groups, intervention with extracts of dates (5 g), grape seed (20 mg), or dill seeds (15 mg) plus routine care and oxytocin, placebo control, hemorrhage measured at 1 and 2 hours after delivery
Blinding
Double-blind
Duration
2 hours
Funding
Unclear

Background

Postpartum hemorrhage (PPH) is one of the three leading causes of maternal mortality. Herbal medicine is one of the well-known methods of treatment in the world.

Objective

This study was conducted to determine and compare the effect of dates, grape seed and dill seed extracts on the PPH rate in women in the fourth stage of labor.

Methods

Two hundred eligible multiparous women visiting the maternity ward in Hamadan for normal delivery participated in this double-blind parallel-group clinical trial. They were randomly divided into four 50-member groups of experiment (3 groups) and control (1 group). The data were collected using a researcher-made questionnaire. In the experimental groups, in addition to routine care and oxytocin administration, the mothers received a capsule containing 15 mg of dill seeds extract or 20 mg of grape seed extract or 5 g of dates extract immediately after the delivery, and then their hemorrhage rates were measured one and two hours after delivery. The control group received routine care, oxytocin, and placebo. Data were analyzed in SPSS 21.

Results

The hemorrhage changes in the placebo group were much less than the intervention groups at 1 and 2 hours after delivery, and the four groups had a significant difference in terms of hemorrhage in both hours (p <0.001). The overall difference between the dates extract group and the placebo and grape seed groups was also statistically significant (p <0.05).

Conclusion

All three extracts of dates, grape seed and dill seeds, especially dates, can be effective in PPH reduction.

Research Insights

  • Red Grape→Reduced Postpartum Hemorrhage Rate

    The hemorrhage changes in the placebo group were much less than the intervention groups at 1 and 2 hours after delivery, and the four groups had a significant difference in terms of hemorrhage in both hours (p <0.001).

    Effect
    Beneficial
    Effect size
    Small
    Dose
    20 mg
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