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Diarrhea in Preschool Children and Lactobacillus reuteri: A Randomized Controlled Trial

  • 2014-04-01
  • Pediatrics 133(4)
    • P. Gutiérrez-Castrellón
    • G. López-Velázquez
    • Luisa Díaz-García
    • C. Jiménez-Gutiérrez
    • J. Mancilla-Ramírez
    • Juliana Estevez-Jiménez
    • M. Parra

Abstract

Objectives: To evaluate whether daily administration of Lactobacillus reuteri DSM 17938 reduces the frequency and duration of diarrheal episodes and other health outcomes in day school children in Mexico.

Methods: Healthy children (born at term, aged 6-36 months) attending day care centers were enrolled in this randomized, double-blind, placebo-controlled trial. They received L reuteri DSM 17938 (dose 10(8) colony-forming unit; n = 168) or identical placebo (n = 168) by mouth, daily for 3 months, after which they were followed-up after a further 3 months without supplementation.

Results: Data from all children were included in the final analysis. L reuteri DSM 17938 significantly reduced the frequency and duration of episodes of diarrhea and respiratory tract infection at both 3 and 6 months (P < .05). Additionally, the number of doctor visits, antibiotic use, absenteeism from day school and parental absenteeism from work were significantly reduced in the L reuteri group (P < .05). A cost-benefit analysis revealed significant reductions in costs in the L reuteri-treated children. No adverse events related to the study product were reported.

Conclusions: In healthy children attending day care centers, daily administration of L reuteri DSM 17938 had a significant effect in reducing episodes and duration of diarrhea and respiratory tract infection, with consequent cost savings for the community.

Trial registration: ClinicalTrials.gov NCT01249911.

Keywords: Lactobacillus reuteri DSM 17938; children; diarrhea.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus reuteriReduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteriReduced Diarrhea FrequencyBeneficial
Large
Lactobacillus reuteriReduced Doctor VisitsBeneficial
Large
Lactobacillus reuteriReduced Duration of DiarrheaBeneficial
Large
Lactobacillus reuteriReduced Frequency of Respiratory Tract InfectionsBeneficial
Large
Lactobacillus reuteriReduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteriReduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri DSM 17938Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Diarrhea FrequencyBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Doctor VisitsBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Duration of DiarrheaBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Duration of Respiratory Tract InfectionsBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Frequency of Respiratory Tract InfectionsBeneficial
Large
Lactobacillus reuteri DSM 17938Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri DSM 17938Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri HA-188Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri HA-188Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus reuteri HA-188Reduced Doctor VisitsBeneficial
Large
Lactobacillus reuteri HA-188Reduced Healthcare CostsBeneficial
Large
Lactobacillus reuteri HA-188Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri HA-188Reduced Respiratory Tract Infection EpisodesBeneficial
Large
Lactobacillus reuteri HA-188Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri NCIMB 30242Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri NCIMB 30242Reduced Community Healthcare CostsBeneficial
Moderate
Lactobacillus reuteri NCIMB 30242Reduced Doctor VisitsBeneficial
Large
Lactobacillus reuteri NCIMB 30242Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri NCIMB 30242Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri OsfortisReduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri OsfortisReduced Doctor VisitsBeneficial
Large
Lactobacillus reuteri OsfortisReduced Healthcare CostsBeneficial
Large
Lactobacillus reuteri SD-5865Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri SD-5865Reduced Community Healthcare CostsBeneficial
Moderate
Lactobacillus reuteri SD-5865Reduced Doctor VisitsBeneficial
Large
Lactobacillus reuteri SD-5865Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri SD-5865Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri UALg-05Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri UALg-05Reduced Community Healthcare CostsBeneficial
Moderate
Lactobacillus reuteri UALg-05Reduced Diarrhea FrequencyBeneficial
Large
Lactobacillus reuteri UALg-05Reduced Duration of DiarrheaBeneficial
Large
Lactobacillus reuteri UALg-05Reduced Duration of Respiratory Tract InfectionsBeneficial
Large
Lactobacillus reuteri UALg-05Reduced Frequency of Respiratory Tract InfectionsBeneficial
Large
Lactobacillus reuteri UALg-05Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri UALg-05Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate
Lactobacillus reuteri UALre-16Reduced Antibiotic UsageBeneficial
Large
Lactobacillus reuteri UALre-16Reduced Community Healthcare CostsBeneficial
Moderate
Lactobacillus reuteri UALre-16Reduced Parental Absenteeism from WorkBeneficial
Moderate
Lactobacillus reuteri UALre-16Reduced School Absenteeism Due to Infectious DiseasesBeneficial
Moderate

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