Skip to main content

Abstract

Lactobacillus rhamnosus GG (LGG) has been regarded as a safe probiotic strain. The aim of this study was to investigate whether dietary LGG supplementation could alleviate diarrhea via improving jejunal mucosal barrier function in the weaned piglets challenged by RV, and further analyze the potential roles for apoptosis of jejunal mucosal cells and intestinal microbiota. A total of 24 crossbred barrows weaned at 21 d of age were assigned randomly to 1 of 2 diets: the basal diet and LGG supplementing diet. On day 11, all pigs were orally infused RV or the sterile essential medium. RV infusion increased the diarrhea rate, increased the RV-Ab, NSP4 and IL-2 concentrations and the Bax mRNA levels of jejunal mucosa (P<0.05), decreased the villus height, villus height: crypt depth, the sIgA, IL-4 and mucin 1 concentrations and the ZO-1, occludin and Bcl-2 mRNA levels of jejunal mucosa (P<0.05), and affected the microbiota of ileum and cecum (P<0.05) in the weaned pigs. Dietary LGG supplementation increased the villus height and villus height: crypt depth, the sIgA, IL-4, mucin 1 and mucin 2 concentrations, and the ZO-1, occludin and Bcl-2 mRNA levels of the jejunal mucosa (P<0.05) reduced the Bax mRNA levels of the jejunal mucosa (P<0.05) in weaned pigs. Furthermore, dietary LGG supplementation alleviated the increase of diarrhea rate in the weaned pigs challenged by RV (P<0.05), and relieve the effect of RV infection on the villus height, crypt depth and the villus height: crypt depth of the jejunal mucosa (P<0.05), the NSP4, sIgA, IL-2, IL-4, mucin 1 and mucin 2 concentrations of jejunal mucosa (P<0.05), the ZO-1, occludin, Bax and Bcl-2 mRNA levels of the jejunal mucosa (P<0.05), and the microbiota of ileum and cecum (P<0.05) in the weaned pigs challenged by RV. These results suggest that supplementing LGG in diets alleviated the diarrhea of weaned piglets challenged by RV via inhibiting the virus multiplication and improving the jejunal mucosal barrier function, which was possibly due to the decreasing apoptosis of jejunal mucosal cells and the improvement of intestinal microbiota.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus rhamnosusImproved Immunologic Barrier FunctionBeneficial
Moderate
Lacticaseibacillus rhamnosusReduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lacticaseibacillus rhamnosusReduced Diarrhea IncidenceBeneficial
Large
Lacticaseibacillus rhamnosusRegulated Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosusImproved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosusImproved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosusReduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosusReduced Diarrhea RateBeneficial
Large
Lactobacillus rhamnosus CLR1505Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus CLR1505Improved Intestinal Microbial CompositionBeneficial
Large
Lactobacillus rhamnosus CLR1505Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus CLR1505Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus CRL 1505Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus CRL 1505Improved Intestinal Microbial CompositionBeneficial
Large
Lactobacillus rhamnosus CRL 1505Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus CRL 1505Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus DSM33560Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus DSM33560Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus DSM33560Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus GGImproved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus GGImproved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus GGReduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus GGReduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus HA-11Reduced Inflammatory ResponseBeneficial
Moderate
Lactobacillus rhamnosus HA-111Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus HA-111Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus HA-111Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus HA-500Altered Cytokine Levels in Jejunal MucosaBeneficial
Moderate
Lactobacillus rhamnosus HA-500Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus HA-500Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus HA-500Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus HA-500Reduced DiarrheaBeneficial
Large
Lactobacillus rhamnosus HA-500Reduced Viral LoadBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Improved Gut MicrobiotaBeneficial
Large
Lactobacillus rhamnosus IMC 501Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus IMC 501Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus IMC 501Reduced Diarrhea RateBeneficial
Large
Lactobacillus rhamnosus LR04Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus LR04Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus LR04Reduced Diarrhea SymptomsBeneficial
Large
Lactobacillus rhamnosus LR05Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus LR05Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LR05Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus LR05Reduced Diarrhea SymptomsBeneficial
Large
Lactobacillus rhamnosus LR05Reduced RSV ReplicationBeneficial
Large
Lactobacillus rhamnosus LR06Improved Gut MicrobiotaBeneficial
Large
Lactobacillus rhamnosus LR06Improved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus LR06Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus LRa05Improved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus LRa05Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus LRa05Reduced Diarrhea RateBeneficial
Large
Lactobacillus rhamnosus lysate powderImproved Gut MicrobiotaBeneficial
Large
Lactobacillus rhamnosus lysate powderImproved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus lysate powderReduced Diarrhea SymptomsBeneficial
Large
Lactobacillus rhamnosus MAK79L08RImproved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RImproved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RReduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus MAK79L08RReduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus NH001Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus NH001Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus NH001Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus NH001Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus NH001Reduced RSV ReplicationBeneficial
Large
Lactobacillus rhamnosus PXN 54Improved Intestinal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus PXN 54Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus PXN 54Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus PXN 54Reduced Diarrhea SymptomsBeneficial
Large
Lactobacillus rhamnosus R0011Improved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus R0011Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus R0011Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus R0011Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus R0343NDImproved Immune ResponseBeneficial
Moderate
Lactobacillus rhamnosus R0343NDImproved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus R0343NDImproved Intestinal Mucosal Barrier FunctionBeneficial
Large
Lactobacillus rhamnosus R0343NDReduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus R0343NDReduced Diarrhea SymptomsBeneficial
Large
Lactobacillus rhamnosus UALr-18Improved Immunologic Barrier FunctionBeneficial
Moderate
Lactobacillus rhamnosus UALr-18Improved Intestinal MicrobiotaBeneficial
Moderate
Lactobacillus rhamnosus UALr-18Reduced Apoptosis of Jejunal Mucosal CellsBeneficial
Moderate
Lactobacillus rhamnosus UALr-18Reduced Diarrhea IncidenceBeneficial
Large
Lactobacillus rhamnosus UALr-18Reduced Impact of Rhinovirus InfectionBeneficial
Moderate
Lactobacillus rhamnosus UALrh-18Reduced Diarrhea RateBeneficial
Large

Pillser helps you make informed health decisions by providing comprehensive, unbiased information about supplements. This includes detailed research on supplement ingredients, their benefits, potential risks, and their overall efficacy. You can contribute by sharing your feedback and suggestions.

Send us an email at support@pillser.com.