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Does the Grape Products Intake has an Effect on Body Weight in Adults: A Systematic Review and Meta-analysis of Randomized Controlled Trials.

  • 2024-02
  • Current drug targets 25(2)
    • Mohammad Ali Goudarzi
    • Zahra Sohrabi
    • Mohammad Hashem Hashempur
    • Saeed Nosratabadi
    • Zahra Namkhah
    • Cain C T Clark
    • Neda Haghighat

Study Design

Type
Meta-Analysis
Sample size
n = 1,284
Population
obese participants (30 studies with 35 effect sizes, including 1284 participants)
Methods
Systematic review and meta-analysis of randomized controlled trials; random-effects model to calculate weighted mean differences with 95% CI

Introduction

There is a growing interest in the considerable benefits of grape products intake, as some studies have indicated that they may improve cardiometabolic risk factors. However, the widespread impact of grape products on the anthropometric indices is not fully resolved.

Method

The purpose of this systematic review and meta-analysis was to examine the effects of grape products intake on anthropometric indices in adults. Randomized controlled trials (RCT) examining the effects of grape products intake on anthropometric indices, published up to December 2021, were identified through PubMed, SCOPUS, and ISI Web of Science databases. 30 studies with 35 effect sizes, including 1284 participants (708 cases and 576 controls), were included and analyzed using a random-effects model to calculate weighted mean differences (WMDs) with 95% confidence interval (CI).

Result

The outcomes have revealed grape products intake to significantly decrease body weight (p = 0.001) and body mass index (p = 0.004) in obese participants, and also, a greater effect was observed when grape seed extract was used.

Conclusion

Our study suggests that grape products intake may help to decrease body weight in obese participants. Future large RCTs with longer duration and obese populations are needed to expand our findings.

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