Effect of a fermented milk containing Bifidobacterium lactis DN-173010 on Chinese constipated women.
- 2008
- World Journal of Gastroenterology 14(40)
- Yue-xin Yang
- M. He
- Gang Hu
- Jie Wei
- P. Pagès
- Xiankui Yang
- S. Bourdu-Naturel
- PubMed: 18985817
- DOI: 10.3748/WJG.14.6237
Abstract
Aim: To investigate the effect of a fermented milk containing Bifidobacterium lactis DN-173010 and yogurt strains (BIO(R)) on adult women with constipation in Beijing.
Methods: A total of 135 adult females with constipation were randomly allocated to consume for 2 wk either 100 g of the test fermented milk or 100 g of an acidified milk containing non-living bacteria (control). Stool frequency, defecation condition scores, stool consistency and food intake were recorded at baseline and after 1 and 2 wk in an intention-to-treat population of 126 subjects. In parallel, safety evaluation parameters were performed.
Results: At baseline, no differences were found between groups. Following consumption of test product, stool frequency was significantly increased after 1 wk (3.5 +/- 1.5 vs 2.4 +/- 0.6, P < 0.01) and 2 wk (4.1 +/- 1.7 vs 2.4 +/- 0.6, P < 0.01), vs baseline. Similarly, after 1 and 2 wk, of test product consumption, defecation condition (1.1 +/- 0.9 vs 1.9 +/- 1.2, P < 0.01 and 0.8 +/- 1.0 vs 1.9 +/- 1.2, P < 0.01, respectively) and stool consistency (1.0 +/- 0.8 vs 1.5 +/- 1.1, P < 0.01 and 0.6 +/- 0.8 vs 1.5 +/- 1.1, P < 0.01, respectively) were significantly improved. Compared with the control group, stool frequency was also significantly increased (3.5 +/- 1.5 vs 2.5 +/- 0.9, P < 0.01 and 4.1 +/- 1.7 vs 2.6 +/- 1.0, P < 0.01, respectively), and defecation condition (1.1 +/- 0.9 vs 1.6 +/- 1.1, P < 0.01 and 0.8 +/- 1.0 vs 1.6 +/- 1.1, P < 0.01, respectively) and stool consistency (1.0 +/- 0.8 vs 1.4 +/- 1.0, P < 0.05 and 0.6 +/- 0.8 vs 1.3 +/- 1.0, P < 0.01, respectively) significantly decreased after 1 and 2 wk of product consumption. During the same period, food intake did not change between the two groups, and safety parameters of the subjects were within normal ranges.
Conclusion: This study suggests a beneficial effect of a fermented milk containing B. lactis DN-173010 on stool frequency, defecation condition and stool consistency in adult women with constipation constipated women after 1 and 2 wk of consumption.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Bifidobacterium | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium | Maintained Food Intake | Neutral | Small |
Bifidobacterium lactis | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis B420 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis B420 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis B420 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis BI-04 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis BI-04 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis BI-04 | Improved Stool Frequency | Beneficial | Moderate |
Bifidobacterium lactis Bi-07 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis Bi-07 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis Bi-07 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis Bl-04 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis Bl-04 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis Bl-04 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis BL818 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis BL818 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis BL818 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis BL818 | Normal Safety Parameters | Neutral | Small |
Bifidobacterium lactis BLA80 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis BLA80 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis BLA80 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis BLC-1 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis BLC-1 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis BLC-1 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis BLC-1 | Normal Safety Parameters | Neutral | Small |
Bifidobacterium lactis BS01 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis BS01 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis BS01 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis HA-194 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis HA-194 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis HA-194 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis HN019 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis HN019 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis HN019 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis ISS Bif | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis ISS Bif | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis ISS Bif | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis MAK16B42L | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis MAK16B42L | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis MAK16B42L | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis R101-8 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis R101-8 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis R101-8 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis SD-5219 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis SD-5219 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis SD-5219 | Increased Stool Frequency | Beneficial | Large |
Bifidobacterium lactis UABla-12 | Improved Bowel Movement Frequency | Beneficial | Large |
Bifidobacterium lactis UABla-12 | Improved Defecation Condition | Beneficial | Large |
Bifidobacterium lactis UABla-12 | Improved Stool Consistency | Beneficial | Moderate |
Bifidobacterium lactis UABla-12 | Improved Stool Frequency | Beneficial | Moderate |
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