Skip to main content
Supplement Research and Comparison WebsiteBest Price Guarantee
Supplement Research and Comparison Website

Effect of Dietary Lactobacillus casei on Physiometabolic Responses and Liver Histopathology in Common Carp (Cyprinus carpio) After Exposure to Iron Oxide Nanoparticles

  • 2021-08-30
  • Biological Trace Element Research 200(7)
    • S. Hedayati
    • Rouhollah Sheikh Veisi
    • Seyed Pezhman Hosseini Shekarabi
    • Saeid Shahbazi Naserabad
    • D. Bagheri
    • Hamed Ghafarifarsani

Abstract

A 60-day feeding trial was performed to assess the dietary effect of Lactobacillus casei as a probiotic supplement on some serum biochemical parameters and liver histopathology in common carp fry after exposure to iron oxide nanoparticles (IoNPs). Six treatments were prepared as follows: control (no IoNP exposure and no dietary probiotic), P6: 106 CFU/g probiotic diet, P7: 107 CFU/g probiotic diet, NPs: 0.15 mg/l IoNPs, NPs + P6: 0.15 mg/l IoNPs with 106 CFU/g probiotic diet, and NPs + P7: 0.15 mg/l IoNPs with 107 CFU/gprobiotic diet. Based on the results, serum aspartate aminotransferase and alanine aminotransferase levels were significantly increased in 0.15 mg/l IoNPs, P7, and NPs + P6 treatments compared to the control group. In addition, the examination of antioxidant enzymes showed a significant increase in the levels of cortisol and glutathione S-transferase as well as malondialdehyde level. IoNPs also caused significant histopathological changes in the fish liver during the experiment such as hyperemia in sinusoidal spaces, hepatocytes vacuolation and necrosis, pyknosis, and disruption of hepatic lobules and atrophy. Results revealed the protective effects of dietary L. casei to mitigate the adverse impacts of IoNPs on the physiological processes of common carp.

Keywords: Fe2O3 nanoparticles; Hepatic enzymes; Histopathology; Nanoecotoxicity; Nanomaterials; Probiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus caseiIncreased Malondialdehyde LevelsHarmful
Moderate
Lacticaseibacillus caseiLiver Histopathological DamageHarmful
Large
Lacticaseibacillus caseiReduced Adverse Effects of IoNPsBeneficial
Moderate
Lacticaseibacillus casei R0215Increased Liver Enzyme LevelsHarmful
Moderate
Lacticaseibacillus casei R0215Increased Protection Against Iron Oxide NanoparticlesBeneficial
Moderate
Lacticaseibacillus casei R0215Increased Stress BiomarkersHarmful
Large
Lacticaseibacillus casei R0215Liver Histopathological DamageHarmful
Large
Lactobacillus caseiReduced Adverse Impacts of Iron Oxide NanoparticlesBeneficial
Moderate
Lactobacillus casei HA-108Mitigated Adverse Impacts of IoNPs on Physiological ProcessesBeneficial
Large
Lactobacillus casei PXN 37Elevated Serum Alanine Aminotransferase LevelsHarmful
Moderate
Lactobacillus casei PXN 37Elevated Serum Aspartate Aminotransferase LevelsHarmful
Large
Lactobacillus casei PXN 37Reduced Hepatotoxicity from Iron Oxide NanoparticlesBeneficial
Moderate
Lactobacillus casei PXN 37Significant Histopathological Changes in LiverHarmful
Large
Lactobacillus casei R0215Elevated Malondialdehyde LevelsHarmful
Moderate
Lactobacillus casei R0215Elevated Serum Alanine Aminotransferase LevelsHarmful
Moderate
Lactobacillus casei R0215Increased Colonic Mucosal Glutathione S-Transferase LevelsHarmful
Moderate
Lactobacillus casei R0215Increased Cortisol LevelsHarmful
Moderate
Lactobacillus casei R0215Reduced Hepatotoxicity from Iron Oxide NanoparticlesBeneficial
Moderate
Lactobacillus casei SD-5213Elevated Serum Enzyme LevelsHarmful
Moderate
Lactobacillus casei SD-5213Liver Histopathological DamageHarmful
Large
Lactobacillus casei SD-5213Reduced Adverse Effects of IoNPsBeneficial
Moderate
Lactobacillus casei SD-5842Reduced Adverse Physiometabolic EffectsBeneficial
Moderate
Lactobacillus casei subsp. caseiElevated Hepatic Enzyme LevelsHarmful
Large
Lactobacillus casei subsp. caseiImproved Antioxidant Enzyme LevelsNeutral
Moderate
Lactobacillus casei subsp. caseiLiver Histopathological DamageHarmful
Large
Lactobacillus casei subsp. caseiProtection Against Impact of IoNPsBeneficial
Moderate
Lactobacillus casei UALc-03Mitigated Adverse Physiological ProcessesBeneficial
Moderate
Lactobacillus casei UALc-03Reduced Liver DamageBeneficial
Moderate
Lactobacillus casei VK4Liver Histopathological DamageHarmful
Large
Lactobacillus casei VK4Reduced Adverse Effects of IoNPsBeneficial
Moderate
Back to top