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Effect of Heat-Treated Lactiplantibacillus plantarum nF1 on the Immune System Including Natural Killer Cell Activity: A Randomized, Placebo-Controlled, Double-Blind Study.

  • 2024-04-29
  • Nutrients 16(9)
    • Geun-Hye Hong
    • So-Young Lee
    • In Ah Kim
    • Jangmi Suk
    • Chaemin Baeg
    • Ji Yeon Kim
    • Sehee Lee
    • Kyeong Jin Kim
    • Ki Tae Kim
    • Min Gee Kim
    • Kun-Young Park

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 100
Population
100 subjects with normal white blood cell counts
Methods
randomized, double-blind, placebo-controlled study; HT-nF1 group administered capsules containing 5 × 10^11 cells of HT-nF1 once a day for 8 weeks
Blinding
Double-blind
Duration
8 weeks
Funding
Unclear
  • Large Human Trial
  • Rigorous Journal
Heat-treated Lactiplantibacillus plantarum nF1 (HT-nF1) increases immune cell activation and the production of various immunomodulators (e.g., interleukin (IL)-12) as well as immunoglobulin (Ig) G, which plays an important role in humoral immunity, and IgA, which activates mucosal immunity. To determine the effect of HT-nF1 intake on improving immune function, a randomized, double-blind, placebo-controlled study was conducted on 100 subjects with normal white blood cell counts. The HT-nF1 group was administered capsules containing 5 × 1011 cells of HT-nF1 once a day for 8 weeks. After 8 weeks of HT-nF1 intake, significant changes in IL-12 were observed in the HT-nF1 group (p = 0.045). In particular, the change in natural killer (NK) cell activity significantly increased in subjects with low secretory (s) IgA (≤49.61 μg/mL) and low NK activity (E:T = 10:1) (≤3.59%). These results suggest that HT-nF1 has no safety issues and improves the innate immune function by regulating T helper (Th)1-related immune factors. Therefore, we confirmed that HT-nF1 not only has a positive effect on regulating the body's immunity, but it is also a safe material for the human body, which confirms its potential as a functional health food ingredient.

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