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Effect of L-Citrulline Supplementation on Blood Pressure: a Systematic Review and Meta-Analysis of Clinical Trials.

  • 2018-10-03
  • Current hypertension reports 20(11)
    • Mohammad Sadegh Mirenayat
    • Sajjad Moradi
    • Hamed Mohammadi
    • Mohammad Hossein Rouhani

Study Design

Type
Meta-Analysis
Population
human clinical trials
Methods
systematic review and meta-analysis of interventional studies; Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018

Purpose of review

Several interventional studies assessed the impact of dietary supplements on blood pressure. The aim of the present systematic review and meta-analysis was to determine the efficacy of L-citrulline supplementation on blood pressure.

Recent finding

Pubmed, Scopus, Google Scholar, and ISI Web of Science were comprehensively searched until May 2018 to assess whether L-citrulline reduces blood pressure. Human clinical trials which reported the effect of L-citrulline supplementation on aortic and brachial blood pressure were included. Characteristics of studies and potential sources of heterogeneity were tabulated. A subgroup analysis was performed to attenuate observed inter-study heterogeneity. A total of five interventions were found for meta-analysis. The impact of L-citrulline on brachial systolic (change 0.28 mmHg; 95% CI - 2.87, 2.31 mmHg) and diastolic (change - 1.56 mmHg; 95% CI - 4.32, 1.20 mmHg) blood pressure was not significant. Also, there was no changes in aortic systolic (change 0.22 mmHg; 95% CI - 4.81, 4.38 mmHg) and diastolic (change 0.26 mmHg; 95% CI - 2.27, 2.80 mmHg) blood pressure after L-citrulline supplementation. Participants' body weight status was a source of observed heterogeneity. The present systematic review and meta-analysis suggests that L-citrulline supplementation had no beneficial effect on blood pressure.

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