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Effect of Lactobacillus plantarum CJLP243 on the growth performance and cytokine response of weaning pigs challenged with enterotoxigenic Escherichia coli.

  • 2012-11-01
  • Journal of Animal Science 90(11)
    • J. S. Lee
    • E. Awji
    • S. J. Lee
    • D. Tassew
    • Y. B. Park
    • K. Park
    • M. K. Kim
    • B. Kim
    • S. C. Park

Abstract

The purpose of the present study was to evaluate the effect of diets containing Lactobacillus plantarum CJLP243 on the growth and cytokine response of weaning pigs (Sus scrofa) challenged with enterotoxigenic Escherichia coli (ETEC). In a 28-d experiment (14 d before and 14 d after challenge), a total of 108 pigs at 20 ± 1 d of age were allotted to 1 of 6 diets. These were a control diet without ETEC challenge (CON) and 5 treatment diets with ETEC challenge, including a control diet with ETEC challenge (negative control, NC); a positive control diet containing antibiotics (PC); control diet plus (10(8), 10(9), or 10(10)) cfu/kg L. plantarum CJLP243 (T1, T2, and T3, respectively). After challenge, NC showed the least ADFI, whereas PC and T3 had the greatest ADFI (P = 0.002). The ADG of PC, T2, and T3 were greater (P = 0.001) than that of CON, NC, and T1 during wk 1 to wk 2. During wk 3 to wk 4, a marked decline was seen in NC (P = 0.001) compared with CON, whereas PC and T3 showed increased ADG (P = 0.001). The overall ADG of PC and T3 were greater (P < 0.001) than the remaining groups. The PC and T3 had the greatest G:F during the second 2 wk (P = 0.002), and the overall 4-wk experimental period (P = 0.003). At 3 h after challenge, all groups except CON had greater rectal temperatures (RT; P < 0.05). The RT decreased to prechallenge temperatures at 9 h (PC and T3), 24 h (T1 and T2), and remained increased until d 7 in NC. At 7 and 14 d postinfection, the number of animals detected positive for ETEC by PCR assay was the greatest in NC; however, the PC group had the fewest ETEC-positive animals (P < 0.05), which was similar to T3. All challenged pigs, except T2, had greater concentrations of serum haptoglobin compared with CON, with the greatest concentration observed in NC (P < 0.001). Challenged pigs had increased serum concentrations of tumor necrosis factor alpha (TNF-α) 3 to 48 h postinfection, with the greatest concentration of TNF-α at 48 h observed in NC (P < 0.05). Similarly, greater (P < 0.05) serum concentrations of interferon-γ were observed for 9 h (T1 and T3), 24 h (T2 and PC), and 48 h (NC) postinfection. The serum concentration of IL-6 increased (P < 0.05) for 3 h in T3 and 24 h in NC. In conclusion, our findings suggest that L. plantarum CJLP243, at a concentration of 10(10) cfu/kg, may serve as a potential alternative to antibiotic supplementation to improve the growth and health performance of weaning pigs, especially during acute inflammation of the gut after bacterial infections.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarum UALp-05Improved Feed EfficiencyBeneficial
Large
Lactobacillus plantarum UALp-05Improved Growth PerformanceBeneficial
Large
Lactobacillus plantarum UALp-05Improved Reaction TimeBeneficial
Moderate
Lactobacillus plantarum UALp-05Reduced ETEC-Positive AnimalsBeneficial
Moderate
Lactobacillus plantarum UALp-05Reduced Serum Haptoglobin LevelsBeneficial
Large
Lactobacillus plantarum UALp-05Reduced Serum Interferon GammaBeneficial
Moderate
Lactobacillus plantarum UALp-05Reduced Serum TNF-α LevelsBeneficial
Moderate
Lactobacillus plantarum UALp-05MAltered Serum IL-6 LevelsNeutral
Small
Lactobacillus plantarum UALp-05MImproved Feed EfficiencyBeneficial
Large
Lactobacillus plantarum UALp-05MImproved Growth PerformanceBeneficial
Large
Lactobacillus plantarum UALp-05MReduced ETEC PrevalenceBeneficial
Large
Lactobacillus plantarum UALp-05MReduced Growth Decline After InfectionBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Rectal TemperatureBeneficial
Large
Lactobacillus plantarum UALp-05MReduced Serum Haptoglobin LevelsBeneficial
Large
Lactobacillus plantarum UALp-05MReduced Serum Interferon GammaBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Tumor Necrosis Factor AlphaBeneficial
Large
Lactobacillus plantarum VPro 10Improved Average Daily Feed IntakeBeneficial
Large
Lactobacillus plantarum VPro 10Improved Average Daily GainBeneficial
Large
Lactobacillus plantarum VPro 10Improved Feed Conversion RatioBeneficial
Large
Lactobacillus plantarum VPro 10Reduced ETEC-Positive AnimalsBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced IL-6 ConcentrationBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Rectal TemperatureBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Serum Haptoglobin LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Serum TNF-α LevelsBeneficial
Moderate

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