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Abstract

Previous studies on a murine model have demonstrated that the administration of Lactobacillus helveticus and Lactobacillus casei inhibits the development of fibrosarcoma and colon carcinoma, respectively. The aim of this work was to study the beneficial effects of the consumption of milk fermented by L. helveticus on a murine model for mammary carcinoma. Female BALB/c mice were challenged by a single subcutaneous injection of tumoral cells (American Type Culture Collection 4T1) in the left mammary gland. Prior to tumour injection, mice were fed for two, five or seven consecutive days with fermented milk. The following factors were monitored for 2 months: rate of tumour development, histological studies, apoptosis, phagocytic index, peritoneal macrophages, determination of beta-glucuronidase enzyme in peritoneal macrophages, determination of gamma-interferon (INFgamma) and tumour necrosis factor-alpha (TNF-alpha) in blood serum, determination of CD4+, CD8+, interleukin-6 (IL-6), IL-10, TNF-alpha and INFgamma by immunoperoxidase, and measurement of beta-glucuronidase activity in intestinal fluid. The administration of L. helveticus delayed the development of the tumour in all cases, a 2- or 7-day feeding period being most effective. This work demonstrates that milk fermented with L. helveticus decreases the growth rate of mammary tumours. The effect was mediated by increased apoptosis and decreased production of pro-inflammatory cytokines, in particular IL-6, implicated in oestrogen synthesis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticusDelayed Tumor OnsetBeneficial
Large
Lactobacillus helveticusIncreased Cellular ApoptosisBeneficial
Moderate
Lactobacillus helveticusReduced Proinflammatory Cytokine ProductionBeneficial
Moderate
Lactobacillus helveticus HA-128Delayed Tumor OnsetBeneficial
Large
Lactobacillus helveticus HA-128Increased Cellular ApoptosisBeneficial
Moderate
Lactobacillus helveticus HA-128Reduced Proinflammatory Cytokine ProductionBeneficial
Moderate
Lactobacillus helveticus HA-128Reduced Tumor GrowthBeneficial
Large
Lactobacillus helveticus L10Delayed Tumor OnsetBeneficial
Large
Lactobacillus helveticus L10Increased Cellular ApoptosisBeneficial
Moderate
Lactobacillus helveticus L10Reduced Pro-Inflammatory CytokinesBeneficial
Moderate
Lactobacillus helveticus L10Reduced Tumor GrowthBeneficial
Large
Lactobacillus helveticus LH76Delayed Tumor OnsetBeneficial
Large
Lactobacillus helveticus LH76Increased Cellular ApoptosisBeneficial
Moderate
Lactobacillus helveticus LH76Reduced Proinflammatory Cytokine ProductionBeneficial
Moderate
Lactobacillus helveticus LH76Reduced Tumor GrowthBeneficial
Large
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