Effect of nutritional supports on malnutrition, cognition, function and biomarkers of Alzheimer's disease: a systematic review.

2022-07-03
The International journal of neuroscience 133(12)
- Rümeysa Rabia Kocatürk
- Arzu Temizyürek
- Öznur Özge Özcan
- Türker Tekin Ergüzel
- Mesut Karahan
- Muhsin Konuk
- Nevzat Tarhan

PubMed: 35686376
DOI: 10.1080/00207454.2022.2079506

Study Design

Type: Systematic Review
Sample size: n = 7,009
Population: 7009 AD patients
Methods: PubMed, Web of Science, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Cochrane Library and Scopus databases were searched until 16 April 2021. 22.193 records in total were reached according to inclusion and exclusion criteria. Included Studies were evaluated through the Modified Jadad Scale and gathered under four subheadings.

Aim

To summarize the nutritional supplementation on biochemical parameters, cognition, function, Alzheimer's Disease (AD) biomarkers and nutritional status.

Materials and methods

PubMed, Web of Science, Korean Journal Database, Russian Science Citation Index, SciELO Citation Index, Cochrane Library and Scopus databases were searched until 16 April 2021. 22.193 records in total were reached according to inclusion and exclusion criteria. Included Studies were evaluated through the Modified Jadad Scale and gathered under four subheadings.

Results

Forty-eight studies with a total of 7009 AD patients were included. Souvenaid, ONS (368 ± 69 kcal), Vegenat-med, 500 mg Resveratrol, ONS (200 mL) were effective nutritional supplements on promoting weight gain and protecting malnutrition status but showed conflicting results in Body mass index, Mid-Upper-Arm Circumference and Triceps Skin Fold Thickness. ONS and a lyophilized whole supplementation Vegenat-med intake made an increase in MNA scores. While all nutritional supplements showed controversial results in biochemical parameters but caused a decrease in Hcy levels which caused reductions in brain Aβ plaque (increase serum Aβ), p-Tau and cognitive improvement. Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA. Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.

Conclusions

Better designed trials with holistic measures are needed to investigate the effect of nutritional support on the AD biomarkers, cognitive status, biochemical parameters and functional states. Also, more beneficial results can be obtained by examining the simultaneous effects of nutritional supplements with larger sample groups.

Research Insights

Resveratrol→Improved Cognitive Prognosis
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Dose
500 mg
Resveratrol→Improved Functional Prognosis
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Dose
500 mg
Resveratrol→Improved Malnutrition Status
Souvenaid, ONS (368 ± 69 kcal), Vegenat-med, 500 mg Resveratrol, ONS (200 mL) were effective nutritional supplements on promoting weight gain and protecting malnutrition status
Effect
Beneficial
Effect size
Small
Dose
500 mg
Resveratrol→Improved Quality of Life
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Dose
500 mg
Resveratrol→Promoted Weight Gain
Souvenaid, ONS (368 ± 69 kcal), Vegenat-med, 500 mg Resveratrol, ONS (200 mL) were effective nutritional supplements on promoting weight gain and protecting malnutrition status
Effect
Beneficial
Effect size
Small
Dose
500 mg
Vitamin B9→Reduced Amyloid Precursor Protein Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small
Vitamin B9→Reduced BACE1 Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small
Vitamin B9→Reduced BACE1 mRNA Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Cognitive Prognosis
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Functional Prognosis
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Vitamin D→Improved Quality of Life
Resveratrol, Hericium erinaceus mycelia, vitamin D and Betaine supplements improved cognitive, functional prognosis and quality of life unlike other nutritional supplements had no effect on cognitive scales.
Effect
Beneficial
Effect size
Small
Vitamin D→Reduced Amyloid Precursor Protein Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small
Vitamin D→Reduced BACE1 Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small
Vitamin D→Reduced BACE1 mRNA Level
Folic acid and vitamin D decreased serum APP, BACE1, BACE1mRNA.
Effect
Beneficial
Effect size
Small