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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Improved Quality of Life

Research synthesisLow evidenceMixed effect size3 studies · 3 beneficial · 0 neutral · 0 harmful

Across 3 studies, all reported beneficial effects of vitamin D supplementation on quality of life, with effect sizes ranging from small to moderate. The evidence is based on clinical populations including Alzheimer's disease patients, chronic urticaria patients, and breast cancer patients. One study used doses of 4000 IU/day or 60000 IU/week, but dosing was not consistently reported across studies.

  • Effective dose range: 4000 IU/day or 60000 IU/week
  • Studied populations: patients with Alzheimer's disease, patients with chronic urticaria (especially chronic spontaneous urticaria), women with estrogen/progesterone-receptor-positive breast cancer

Caveats: Evidence base is small (only 3 studies) — conclusions should be considered preliminary. Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Study durations and forms were not consistently reported, limiting specificity of recommendations.

Generated May 16, 2026
Doses used in studies
  • IU/day: 4,000–60,000 (median 32,000, IQR 4,000–60,000) — 1 study
3 of 3 papers
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