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Evidence-Based Supplement Research
Evidence-Based Supplement Research
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Vitamin D and Improved Quality of Life

Research synthesisModerate evidenceSmall effect6 studies · 6 beneficial · 0 neutral · 0 harmful

Across 6 studies, all reported beneficial effects of vitamin D on quality of life, with effect sizes ranging from small to large (predominantly small). The evidence is strongest in clinical populations with Alzheimer's disease, chronic urticaria, and fibromyalgia. Doses used in one systematic review were 4000 IU/day or 60000 IU/week, though most studies did not report dosing details.

  • Effective dose range: 4000 IU/day or 60000 IU/week
  • Studied populations: patients with Alzheimer's disease, chronic urticaria (especially chronic spontaneous urticaria), fibromyalgia, cancer patients, and patients undergoing gastrointestinal surgery

Caveats: Available evidence is overwhelmingly positive — clinical literature in this area is subject to publication bias (null-result studies are less likely to be published or indexed). Most studies had small sample sizes or did not report dosing details, limiting precision. The evidence base is predominantly from systematic reviews and meta-analyses, but individual trial quality varied.

Generated Jun 11, 2026
Doses used in studies
  • IU/day: 4,000–60,000 (median 32,000, IQR 4,000–60,000) — 1 study
6 of 6 papers
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