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Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis.

  • 2025-10-15
  • Nutrients 17(20)
    • Sara Ilari
    • Saverio Nucera
    • Valentina Malafoglia
    • Stefania Proietti
    • Lucia Carmela Passacatini
    • Rosamaria Caminiti
    • Valeria Mazza
    • Alessia Bonaddio
    • Francesca Oppedisano
    • Jessica Maiuolo
    • Daniela Caccamo
    • Marco Tafani
    • Carlo Tomino
    • Vincenzo Mollace
    • William Raffaeli
    • Carolina Muscoli

Study Design

Type
Meta-Analysis
Population
fibromyalgia patients
Methods
systematic review and meta-analysis; literature search in PubMed, Web of Science, and Scopus identified 2776 articles; 7 were included in the systematic review and 4 studies in each meta-analysis
  • Rigorous Journal
Background: Fibromyalgia is a chronic condition characterized by widespread pain, fatigue, and localized tenderness. Its pathophysiology remains unclear, and treatment options are often limited and only partially effective. Recent studies suggest a potential link between vitamin D deficiency and symptom severity, as vitamin D may play a role in modulating pain and inflammation. Methods: This systematic review and meta-analysis assessed the efficacy of vitamin D supplementation in reducing pain and improving quality of life in fibromyalgia patients, focusing on studies up to 31 December 2024. Following PRISMA guidelines, a literature search in PubMed, Web of Science, and Scopus identified 2776 articles; 7 were included in the systematic review and 4 studies in each meta-analysis. Results: Results showed that vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = -0.85; 95% CI: -1.54 to -0.17; p = 0.0148), as well as the FIQ scale (SMD = -0.87; 95% CI: -1.56 to -0.20; p= 0.0115), resulting in an improvement in quality of life. Conclusions: These findings suggest that vitamin D may be a valuable adjunct in fibromyalgia management, particularly for pain. However, further high-quality trials are needed to confirm these effects and identify responsive patient subgroups.

Research Insights

  • Vitamin D→Improved Quality of Life

    as well as the FIQ scale (SMD = -0.87; 95% CI: -1.56 to -0.20; p= 0.0115), resulting in an improvement in quality of life

    Effect
    Beneficial
    Effect size
    Large
  • Vitamin D→Reduced Pain Levels

    vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = -0.85; 95% CI: -1.54 to -0.17; p = 0.0148)

    Effect
    Beneficial
    Effect size
    Large
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