Vitamin D and Reduced Pain Levels

• Does Vitamin D Supplementation Impact Fibromyalgia-Related Pain? A Systematic Review and Meta-Analysis.

  • 2025-10-15
  • Meta-Analysis
  • Nutrients 17(20)
  • • Sara Ilari
    • Saverio Nucera
    • Valentina Malafoglia
    • Stefania Proietti
    • Lucia Carmela Passacatini
    • Rosamaria Caminiti
    • Valeria Mazza
    • Alessia Bonaddio
    • Francesca Oppedisano
    • Jessica Maiuolo
    • Daniela Caccamo
    • Marco Tafani
    • Carlo Tomino
    • Vincenzo Mollace
    • William Raffaeli
    • Carolina Muscoli

  • PubMed: 41156485
  • DOI: 10.3390/nu17203232

  2 Insights on

  • Reduced Pain Levels

  • High evidence
  • Rigorous Journal
  • Clinical

  vitamin D supplementation significantly reduced pain levels compared to the control group, with a statistically significant effect observed using the NRS or VAS (SMD = -0.85; 95% CI: -1.54 to -0.17; p = 0.0148)

  Effect

  Beneficial

  Effect size

  Large

  Significant

  Yes