Effect of probiotic Lactobacillus on lipid profile: A systematic review and meta-analysis of randomized, controlled trials
- 2017-06-08
- PLOS ONE 12(6)
- Yucheng Wu
- Qingqing Zhang
- Yin Ren
- Z. Ruan
- PubMed: 28594860
- DOI: 10.1371/journal.pone.0178868
Abstract
Objective: To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.
Methods: Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.
Results: Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.
Conclusion: Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus Bulgaricus & Lactobacillus Plantarum | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum 14D | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum HA-119 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Reduced Serum Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum L-137 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum R1012 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum R1012 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus plantarum SD-5209 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus reuteri Osfortis | Reduced Low-Density Lipoprotein Level | Beneficial | Moderate |
| Lactobacillus reuteri Osfortis | Reduced Total Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus reuteri UALg-05 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus sporogenes | Improved Triglyceride Levels | Beneficial | Moderate |
| Lactobacillus sporogenes | Increased HDL Cholesterol Levels | Beneficial | Moderate |