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Abstract

Objective: To assess the efficacy of probiotic Lactobacillus on serum lipids using a meta-analysis of randomized, controlled trials.

Methods: Fifteen studies containing 15 trials, with 976 subjects were included. The pooled WMD was calculated by random effects model.

Results: Probiotic Lactobacillus consumption significantly reduced TC by 0.26mmol/l (95% CI, -0.40 to -0.12) and LDL-C by 0.23mmol/l (95% CI, -0.36 to -0.10). Subgroup analysis of trials found significantly reduction of TC using L. plantarum and reduction of LDL-C using L. plantarum or L. reuteri. No significant effects were found on TG and HDL-C levels after supplementation with probiotic Lactobacillus. While, subgroup analysis found significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

Conclusion: Consuming probiotic Lactobacillus, especially L. reuteri and L. plantarm, could reduce TC and LDL-C significantly. The study also suggested significantly beneficial effects on TG and HDL-C by consuming synbiotic food, containing L. sporogenes and inulin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced LDL CholesterolBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarumReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus plantarumReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum 14DReduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum 14DReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Serum Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum R1012Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum R1012Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum UALp-05Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum UALp-05Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus reuteri OsfortisReduced Low-Density Lipoprotein LevelBeneficial
Moderate
Lactobacillus reuteri OsfortisReduced Total Cholesterol LevelsBeneficial
Moderate
Lactobacillus reuteri UALg-05Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus sporogenesImproved Triglyceride LevelsBeneficial
Moderate
Lactobacillus sporogenesIncreased HDL Cholesterol LevelsBeneficial
Moderate
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