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Effectiveness of the short-term use of Cimicifuga racemosa in the endothelial function of postmenopausal women: a double-blind, randomized, controlled trial.

  • 2019-11-06
  • Climacteric : the journal of the International Menopause Society 23(3)
    • E S Fernandes
    • M F S Celani
    • M Fistarol
    • S Geber

Study Design

Type
Randomized Controlled Trial (RCT)
Population
62 healthy postmenopausal women
Methods
Double-blind, randomized, placebo-controlled study; 28 days of 160 mg Cimicifuga racemosa extract (containing 4 mg triterpene glycosides) or placebo
Blinding
Double-blind
Duration
28 days
Funding
Unclear
Objective: This study aimed to assess the effects of daily use of Cimicifuga racemosa on endothelial function through flow-mediated dilation of the brachial artery, when used for 28 days by healthy postmenopausal women.Methods: The double-blind, randomized, placebo-controlled study included two groups of postmenopausal women (n = 31 each). The subjects were clinically assessed and flow-mediated dilation of the brachial artery was measured before and after 28 days of treatment. Patients received dry extract corresponding to 160 mg C. racemosa (extract with 4 mg of triterpene glycosides) or placebo.Results: Mean age, time since menopause, and body mass index in the two groups were similar. The measurements of flow-mediated dilation of the brachial artery, pre and post treatment, respectively, showed a significant increase in patients who used C. racemosa (p = 0.006), unlike patients who used placebo, who did not present changes in the outcome of flow-mediated dilation of the brachial artery after 28 days of use (p ≥ 0.05). When comparing the number of women in both groups who showed an increase in flow-mediated dilation, a significant difference was found in the measurements of the treated group after the use of the medication (p = 0.018).Conclusions: Daily use of 160 mg C. racemosa extract by postmenopausal women for 28 days beneficially influences endothelial function by promoting elasticity of the brachial artery.

Research Insights

  • Black Cohosh→Improved Flow-Mediated Dilation

    The measurements of flow-mediated dilation of the brachial artery, pre and post treatment, respectively, showed a significant increase in patients who used C. racemosa (p=0.006)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    160 mg/day
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