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Effects of administration of Bifidobacterium animalis subsp. lactis GCL2505 on defecation frequency and bifidobacterial microbiota composition in humans.

  • 2012-05
  • Journal of Bioscience and Bioengineering 113(5)
    • Akihiro Ishizuka
    • K. Tomizuka
    • Ryo Aoki
    • Tomohiko Nishijima
    • Yasuo Saito
    • R. Inoue
    • K. Ushida
    • Takashi Mawatari
    • Takayuki Ikeda

Abstract

The aim of this study was to evaluate the changes in endogenous bifidobacteria and administered Bifidobacterium animalis subsp. lactis (B. lactis) GCL2505 (GCL2505) in the intestine after administration of GCL2505 by means of a randomized, placebo-controlled double-blind, cross-over study. An increase in the number of total bifidobacteria (the sum of B. bifidum, B. breve, B. longum subsp. longum, B. adolescentis, B. anglatum, B. catenulatum, B. pseudocatenulatum, B. dentium, B. longum subsp. infantis and B. lactis) in the feces were observed after administration of GCL2505 using species- and subspecies-specific real-time polymerase chain reaction analysis. However, the number of endogenous bifidobacteria species (excluding B. lactis) remained unchanged. B. lactis also became the predominant bifidobacterial species. Taking into account the number of GCL2505 administered, the findings further suggested that GCL2505 proliferated in the intestine. In addition, the defecation frequency increased during GCL2505 administration compared with the placebo. Moreover, a single administration study (n=17) clearly demonstrated that GCL2505 successfully reached the intestine before proliferating at least 10-fold. This is the first report to show an increase in intestinal bifidobacteria, with no changes to the endogenous species, and improvements in constipation following proliferation of administered bifidobacteria.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium animalisImproved ConstipationBeneficial
Moderate
Bifidobacterium animalisIncreased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium animalisIncreased Defecation FrequencyBeneficial
Moderate
Bifidobacterium animalisIncreased Proliferation of Bifidobacterium lactisBeneficial
Moderate
Bifidobacterium animalis subsp. lactisImproved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactisIncreased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium animalis subsp. lactisIncreased Levels of BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Improved ConstipationBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Fecal BifidobacteriaBeneficial
Moderate
Bifidobacterium animalis subsp. lactis B420Increased Proliferation of Bifidobacterium lactisBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Improved ConstipationBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BLC1Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis BS-01Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis CECT 8145No Change in Endogenous Bifidobacteria LevelsNeutral
Small
Bifidobacterium animalis subsp. lactis HN019Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis HN019Increased Intestinal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium animalis subsp. lactis LAFTI B94Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Improved ConstipationBeneficial
Moderate
Bifidobacterium animalis subsp. lactis LAFTI B94Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium animalis subsp. lactis VK2Increased Intestinal Bifidobacteria LevelsBeneficial
Large
Bifidobacterium bifidum/lactis Bb-02Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium bifidum/lactis Bb-02Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium bifidum/lactis Bb-02Relieved ConstipationBeneficial
Moderate
Bifidobacterium lactisImproved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactisIncreased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis B420Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis B420Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis BI-04Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis BI-04Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium lactis BI-04Preserved Endogenous Bifidobacteria CompositionNeutral
Small
Bifidobacterium lactis BI-04Relieved ConstipationBeneficial
Moderate
Bifidobacterium lactis Bi-07Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis Bi-07Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis Bl-04Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis Bl-04Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis Bl-04Relieved ConstipationBeneficial
Moderate
Bifidobacterium lactis BL818Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis BL818Increased Bifidobacterial GrowthBeneficial
Large
Bifidobacterium lactis BL818Relieved ConstipationBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Bifidobacterium lactis GCL2505 Intestinal ProliferationBeneficial
Large
Bifidobacterium lactis BLA80Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium lactis BLA80Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis BLA80No Change in Endogenous Bifidobacteria SpeciesNeutral
Small
Bifidobacterium lactis BLC-1Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis BLC-1Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium lactis BLC-1Increased Defecation FrequencyBeneficial
Moderate
Bifidobacterium lactis BLC-1No Change in Endogenous Bifidobacteria SpeciesNeutral
Small
Bifidobacterium lactis BS01Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis BS01Increased Bifidobacteria ProliferationNeutral
Moderate
Bifidobacterium lactis BS01Increased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis HA-194Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis HA-194Increased Bifidobacteria Levels in IntestineBeneficial
Large
Bifidobacterium lactis ISS BifImproved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis ISS BifIncreased Bifidobacterium lactis Proliferation in the IntestineBeneficial
Large
Bifidobacterium lactis ISS BifIncreased Intestinal Bifidobacteria PopulationBeneficial
Large
Bifidobacterium lactis ISS BifNo Change in Endogenous Bifidobacteria SpeciesNeutral
Small
Bifidobacterium lactis/longumImproved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis/longumIncreased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis/longumSuccessful Gastrointestinal Tract ColonizationBeneficial
Large
Bifidobacterium lactis MAK16B42LImproved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Bacterial ProliferationBeneficial
Large
Bifidobacterium lactis MAK16B42LIncreased Intestinal Bifidobacterium LevelsBeneficial
Moderate
Bifidobacterium lactis MAK16B42LIncreased Probiotic B. lactis LevelsNeutral
Moderate
Bifidobacterium lactis R101-8Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis R101-8Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis R101-8Increased Proliferation of Administered BifidobacteriaBeneficial
Large
Bifidobacterium lactis SD-5219Improved Bowel Movement FrequencyBeneficial
Moderate
Bifidobacterium lactis SD-5219Increased Fecal BifidobacteriaBeneficial
Moderate
Bifidobacterium lactis VK2Increased Bifidobacteria LevelsBeneficial
Moderate
Bifidobacterium lactis VK2No Change in Endogenous Bifidobacteria LevelsNeutral
Small

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