Skip to main content
Evidence-Based Supplement Research
Evidence-Based Supplement Research
Pillser
Search
Sign UpLog In

Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/overweight males during submaximal exercise.

  • 2021-05-20
  • European journal of sport science 22(7)
    • Katherine Dillon
    • Brian Shariffi
    • Trevor Gillum
    • William Boyer
    • Sean Sullivan
    • Jong-Kyung Kim

Study Design

Type
Clinical Trial
Population
overweight and obese males
Methods
7 consecutive days of GSE or placebo (PL) ingestion with one week washout period
Blinding
Double-blind
Duration
7 consecutive days
Funding
Unclear
We investigated the effect of chronic grape seed extract (GSE) on blood pressure and aortic stiffness (AoS) among overweight and obese males. Systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (Q), total vascular conductance (TVC), and AoS were measured during two submaximal cycling exercises (40% and 60% VO2max), after 7 consecutive days of GSE or placebo (PL) ingestion with one week washout period. Compared with PL, GSE supplementation significantly decreased MAP at rest (85 ± 3 mmHg vs. 82 ± 3 mmHg), 40% (102 ± 3 mmHg vs. 99 ± 3 mmHg), and 60% workloads (109 ± 3 mmHg vs. 107 ± 3 mmHg) (P = 0.001, ES = 0.2). AoS was significantly reduced (13.0 ± 1.9 AU vs. 10.2 ± 1.0 AU) at rest (P = 0.002, ES = 0.6). Q was decreased at rest and across all workloads, but there were no significant differences (7.5 ± 0.4 L/min vs. 7.1 ± 0.4 L/min; 20.4 ± 1.2 L/min vs. 19.6 ± 0.9 L/min; 26.3 ± 1.1 L/min vs. 25.5 ± 1.6 L/min, respectively). GSE had no effect on HR, TVC, and SV. Our study indicates that chronic supplementation with GSE reduces arterial pressure at rest and during exercise primarily via the substantial reduction in AoS. Thus, GSE can be a dietary supplement to treat augmented blood pressure responses in obese and overweight males at rest and during exercise.Trial registration: ClinicalTrials.gov identifier: NCT04465110.

Research Insights

  • Red Grape→Reduced Aortic Stiffness

    AoS was significantly reduced (13.0 ± 1.9 AU vs. 10.2 ± 1.0 AU) at rest (P = 0.002, ES = 0.6).

    Effect
    Beneficial
    Effect size
    Moderate
  • Red Grape→Reduced Cardiac Output

    Q was decreased at rest and across all workloads, but there were no significant differences (7.5 ± 0.4 L/min vs. 7.1 ± 0.4 L/min; 20.4 ± 1.2 L/min vs. 19.6 ± 0.9 L/min; 26.3 ± 1.1 L/min vs. 25.5 ± 1.6 L/min, respectively).

    Effect
    Neutral
    Effect size
    Small
  • Red Grape→Reduced Heart Rate

    GSE had no effect on HR, TVC, and SV.

    Effect
    Neutral
    Effect size
    Small
  • Red Grape→Reduced Mean Arterial Pressure

    Compared with PL, GSE supplementation significantly decreased MAP at rest (85 ± 3 mmHg vs. 82 ± 3 mmHg), 40% (102 ± 3 mmHg vs. 99 ± 3 mmHg), and 60% workloads (109 ± 3 mmHg vs. 107 ± 3 mmHg) (P = 0.001, ES = 0.2).

    Effect
    Beneficial
    Effect size
    Small
  • Red Grape→Reduced Stroke Volume

    GSE had no effect on HR, TVC, and SV.

    Effect
    Neutral
    Effect size
    Small
  • Red Grape→Reduced Total Vascular Conductance

    GSE had no effect on HR, TVC, and SV.

    Effect
    Neutral
    Effect size
    Small
Back to top