Effects of Bifidobacterium longum BB536 and Bifidobacterium breve MCC1274 on Body Composition in Normal and Overweight Adults in Randomized Placebo-Controlled Study.

2024-03-13
Nutrients 16(6)

PubMed: 38542727
DOI: 10.3390/nu16060815

Study Design

Type: Randomized Controlled Trial (RCT)
Population: One hundred participants were randomly assigned to the probiotics group or placebo group. Participants were between 29 and 64 years of age and had a body mass index (BMI) of greater than 23 and less than 30.
Methods: randomized, parallel-group, placebo-controlled study; participants were administered probiotic capsules containing 1 × 10^10 CFUs of B. longum BB536 and 5 × 10^9 CFU of B. breve MCC1274 or placebo capsules without bifidobacteria for 16 weeks

Rigorous Journal

Visceral fat accumulation is considered to be associated with a higher risk of chronic diseases. We investigated the effects of Bifidobacterium longum subsp. longum (B. longum) BB536 and Bifidobacterium breve (B. breve) MCC1274 on body composition, including visceral fat, in a randomized, parallel-group, placebo-controlled study. Participants were between 29 and 64 years of age and had a body mass index (BMI) of greater than 23 and less than 30. One hundred participants were randomly assigned to the probiotics group or placebo group. Participants were administered probiotic capsules containing 1 × 10¹⁰ colony-forming units (CFUs) of B. longum BB536 and 5 × 10⁹ CFU of B. breve MCC1274 or placebo capsules without bifidobacteria for 16 weeks. In the probiotics group, abdominal visceral fat area, total abdominal fat area, and serum triglyceride levels were significantly decreased compared to those in the placebo group. Additionally, the increase in BMI observed in the placebo group was significantly suppressed in the probiotics group. This study showed that B. longum BB536 and B. breve MCC1274 reduced abdominal visceral fat and total fat levels in healthy normal and overweight adults, suggesting their beneficial effects on body composition.

Research Insights

Supplement	Dose	Health Outcome	Effect Type	Effect Size	Source
Bifidobacterium longum BB536	—	Reduced Abdominal Fat	Beneficial	Moderate	View source In the probiotics group, abdominal visceral fat area, total abdominal fat area, and serum triglyceride levels were significantly decreased compared to those in the placebo group.
Bifidobacterium longum BB536	—	Reduced Body Mass Index	Beneficial	Small	View source Additionally, the increase in BMI observed in the placebo group was significantly suppressed in the probiotics group.
Bifidobacterium longum BB536	—	Reduced Serum Triglycerides	Beneficial	Small	View source In the probiotics group, abdominal visceral fat area, total abdominal fat area, and serum triglyceride levels were significantly decreased compared to those in the placebo group.
Bifidobacterium longum BB536	—	Reduced Visceral Fat	Beneficial	Moderate	View source In the probiotics group, abdominal visceral fat area, total abdominal fat area, and serum triglyceride levels were significantly decreased compared to those in the placebo group.