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Effects of intake of Lactobacillus casei subsp. casei 327 on skin conditions: a randomized, double-blind, placebo-controlled, parallel-group study in women

  • 2017
  • Bioscience of Microbiota, Food and Health 36(3)
    • Yuhi Saito
    • Toshihiro Mihara
    • Kentaro Maruyama
    • Jiro Saito
    • Masumi Ikeda
    • A. Tomonaga
    • T. Kumagai

Abstract

Lactic acid bacteria are gut flora that play key roles in intestinal homeostasis, which may affect a variety of physiological functions. Our preliminary double-blind, placebo-controlled, parallel-group trials have suggested that intake of heat-killed Lactobacillus casei subsp. casei 327 (designated L. K-1) is effective for improving skin conditions. The aim of this study was to confirm the effect of L. K-1 intake in a randomized, double-blind, placebo-controlled, parallel-group study in healthy female volunteers. Sixty-four subjects were allocated to either the placebo food group (group P, n=32) or active food group (group A, n=32), in which subjects consumed lactobacillus K-1 50 mg (approximately 1 × 1011 bacteria) daily for 8 weeks. After excluding subjects who declined to participate (n=1), violated restrictions (n=4), or were judged ineligible by the principal investigators (n=1), data obtained with 58 subjects (30 in group A and 28 in group P) were analyzed for efficacy by comparing differences from pretrial levels between the two groups. When the level of transepidermal water loss (TEWL) was measured at the arm, the level of TEWL at week 4 of the intake period was significantly lower in group A than group P (p=0.021), suggesting an improvement of skin barrier function. Analysis of skin condition questionnaire data revealed a significant reduction in skin flakiness on the face (week 4). No adverse events were associated with intake of the test foods. The safety of L. K-1 was also confirmed in an independent open-label trial in 11 healthy subjects who consumed excessive amounts of L. K-1 250 mg (approximately 5 × 1011 bacteria). Intake of L. K-1 may therefore be beneficial to skin condition improvement.

Keywords: Lactobacillus casei; clinical study; lactic acid bacteria; skin conditions; transepidermal water loss.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactic Acid Bacteria YK-1Improved Skin Barrier FunctionBeneficial
Moderate
Lactic Acid Bacteria YK-1Reduced Skin FlakinessBeneficial
Moderate
Lactobacillus casei subsp. caseiConfirmed Safety of TreatmentNeutral
Small
Lactobacillus casei subsp. caseiImproved Skin Barrier FunctionBeneficial
Moderate
Lactobacillus casei subsp. caseiReduced Skin FlakinessBeneficial
Moderate
Lactobacillus casei VK4Improved Skin Barrier FunctionBeneficial
Moderate
Lactobacillus casei VK4Reduced Skin FlakinessBeneficial
Moderate

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