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Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet

  • 2009-05-15
  • Applied Microbiology and Biotechnology 84(2)
    • Yanping Wang
    • N. Xu
    • A. Xi
    • Zaheer Ahmed
    • Bin Zhang
    • Xiaojia Bai

Abstract

The objective of this study was to evaluate the effects of Lactobacillus plantarum MA2, an isolate from Chinese traditional Tibet kefir, on cholesterol-lowering and microflora of rat in vivo. Rats were fed on cholesterol-enriched experimental diet, supplemented with lyophilized L. plantarum MA2 powder, with a dose of 10(11) cells/day per mice. The results showed that L. plantarum MA2 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides level, while there was no change in high-density lipoprotein cholesterol. In addition, liver total cholesterol and triglycerides was also decreased. However, fecal cholesterol and triglycerides was increased significantly (P < 0.05) in comparison with the control. Also, L. plantarum MA2 increased the population of lactic acid bacteria and bifidobacteria in the fecal, but it did not change the number of Escherichia coli as compared to control. Moreover, pH, moisture, and organic acids in the fecal were also measured. The present results indicate the probiotic potential of the L. plantarum MA2 strain in hypocholesterolemic effect and also increasing the probiotic count in the intestine.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Bifidobacterium plantarumImproved Gut MicrobiotaBeneficial
Large
Bifidobacterium plantarumReduced Total Cholesterol LevelsBeneficial
Large
Lactobacillus kefirIncreased Bifidobacteria Levels in FecesBeneficial
Moderate
Lactobacillus kefirIncreased Fecal Cholesterol LevelsBeneficial
Moderate
Lactobacillus kefirIncreased Fecal Lactic Acid Bacteria CountsBeneficial
Moderate
Lactobacillus kefirIncreased Fecal Triglyceride LevelsBeneficial
Moderate
Lactobacillus kefirReduced Liver CholesterolBeneficial
Moderate
Lactobacillus kefirReduced Liver TriglyceridesBeneficial
Moderate
Lactobacillus kefirReduced Low-Density Lipoprotein LevelBeneficial
Large
Lactobacillus kefirReduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus kefirReduced Triglyceride LevelsBeneficial
Large
Lactobacillus kefirStable Escherichia coli Population in Fecal MatterNeutral
Small
Lactobacillus kefirStable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Lactobacillus kefiriNo Change in E. coli CountNeutral
Small
Lactobacillus kefiriReduced LDL CholesterolBeneficial
Moderate
Lactobacillus kefiriReduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus kefiriReduced Triglycerides LevelBeneficial
Moderate
Lactobacillus kefiriStable High-Density Lipoprotein Cholesterol LevelNeutral
Small
Lactobacillus plantarum Rosell-1012Increased Fecal Cholesterol LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Increased Fecal Triglyceride LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012No Change in HDL CholesterolNeutral
Small
Lactobacillus plantarum Rosell-1012Reduced Escherichia coli PopulationNeutral
Small
Lactobacillus plantarum Rosell-1012Reduced LDL CholesterolBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Liver Triglyceride ContentBeneficial
Large
Lactobacillus plantarum Rosell-1012Reduced Serum Total CholesterolBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced TriglyceridesBeneficial
Large

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