Effects of Lactobacillus plantarum MA2 isolated from Tibet kefir on lipid metabolism and intestinal microflora of rats fed on high-cholesterol diet
- 2009-05-15
- Applied Microbiology and Biotechnology 84(2)
- Yanping Wang
- N. Xu
- A. Xi
- Zaheer Ahmed
- Bin Zhang
- Xiaojia Bai
- PubMed: 19444443
- DOI: 10.1007/s00253-009-2012-x
Abstract
The objective of this study was to evaluate the effects of Lactobacillus plantarum MA2, an isolate from Chinese traditional Tibet kefir, on cholesterol-lowering and microflora of rat in vivo. Rats were fed on cholesterol-enriched experimental diet, supplemented with lyophilized L. plantarum MA2 powder, with a dose of 10(11) cells/day per mice. The results showed that L. plantarum MA2 feeding significantly lowered serum total cholesterol, low-density lipoprotein cholesterol, and triglycerides level, while there was no change in high-density lipoprotein cholesterol. In addition, liver total cholesterol and triglycerides was also decreased. However, fecal cholesterol and triglycerides was increased significantly (P < 0.05) in comparison with the control. Also, L. plantarum MA2 increased the population of lactic acid bacteria and bifidobacteria in the fecal, but it did not change the number of Escherichia coli as compared to control. Moreover, pH, moisture, and organic acids in the fecal were also measured. The present results indicate the probiotic potential of the L. plantarum MA2 strain in hypocholesterolemic effect and also increasing the probiotic count in the intestine.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Bifidobacterium plantarum | Improved Gut Microbiota | Beneficial | Large |
| Bifidobacterium plantarum | Reduced Total Cholesterol Levels | Beneficial | Large |
| Lactobacillus kefir | Increased Bifidobacteria Levels in Feces | Beneficial | Moderate |
| Lactobacillus kefir | Increased Fecal Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus kefir | Increased Fecal Lactic Acid Bacteria Counts | Beneficial | Moderate |
| Lactobacillus kefir | Increased Fecal Triglyceride Levels | Beneficial | Moderate |
| Lactobacillus kefir | Reduced Liver Cholesterol | Beneficial | Moderate |
| Lactobacillus kefir | Reduced Liver Triglycerides | Beneficial | Moderate |
| Lactobacillus kefir | Reduced Low-Density Lipoprotein Level | Beneficial | Large |
| Lactobacillus kefir | Reduced Serum Total Cholesterol | Beneficial | Moderate |
| Lactobacillus kefir | Reduced Triglyceride Levels | Beneficial | Large |
| Lactobacillus kefir | Stable Escherichia coli Population in Fecal Matter | Neutral | Small |
| Lactobacillus kefir | Stable High-Density Lipoprotein Cholesterol Level | Neutral | Small |
| Lactobacillus kefiri | No Change in E. coli Count | Neutral | Small |
| Lactobacillus kefiri | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus kefiri | Reduced Serum Total Cholesterol | Beneficial | Moderate |
| Lactobacillus kefiri | Reduced Triglycerides Level | Beneficial | Moderate |
| Lactobacillus kefiri | Stable High-Density Lipoprotein Cholesterol Level | Neutral | Small |
| Lactobacillus plantarum Rosell-1012 | Increased Fecal Cholesterol Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Increased Fecal Triglyceride Levels | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | No Change in HDL Cholesterol | Neutral | Small |
| Lactobacillus plantarum Rosell-1012 | Reduced Escherichia coli Population | Neutral | Small |
| Lactobacillus plantarum Rosell-1012 | Reduced LDL Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Liver Triglyceride Content | Beneficial | Large |
| Lactobacillus plantarum Rosell-1012 | Reduced Serum Total Cholesterol | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-1012 | Reduced Triglycerides | Beneficial | Large |