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Effects of Lactobacillus plantarum on the intestinal morphology, intestinal barrier function and microbiota composition of suckling piglets.

  • 2019-09-09
  • Journal of Animal Physiology and Animal Nutrition 103(6)
    • Qi Wang
    • Qian Sun
    • R. Qi
    • Jing Wang
    • Xiaoyu Qiu
    • Zuohua Liu
    • Jinxiu Huang

Abstract

This study investigated the effect of Lactobacillus plantarum strain 299v on gut health in suckling piglets. Sixty newborn piglets were assigned to control and probiotic treatments, with three litters per treatment (ten piglets/litter). From days 1 to 20 of life, piglets were orally administered a placebo of 0.1% peptone or 1.0 × 1010 CFU L. plantarum 299v daily. Six piglets per treatment were sacrificed on day 20, and intestinal tissues (including duodenum, jejunum, ileum and colon) and the intestinal contents from colon segments were collected. The results demonstrated that piglets treated with L. plantarum 299v had a lower diarrhoea incidence than the controls. L. plantarum 299v administration significantly increased the ratio of the villus height to the crypt depth in the jejunum and ileum, as well as the mRNA expression of jejunal occludin and ileal zonula occludens 1 (ZO-1). The L. plantarum treatment also increased the mRNA abundance of porcine β-defensin 2 (pBD2) and pBD3 in the jejunum and ileum and of toll-like receptors (TLRs), such as TLR2, TLR4, TLR6 and TLR9 in the ileum, and significantly upregulated the mRNA abundances of ileal pBD1 and colonic TLR4. Additionally, the L. plantarum 299v treatment significantly changed the structure of the colonic microbiota, as evidenced by the obvious increases in the relative abundances of the phyla Firmicutes and Actinobacteria and of the genus Lactobacillus. Our findings indicate that L. plantarum 299v facilitates the gut health of suckling piglets, probably by improving the intestinal morphology and intestinal barrier function and by modifying the structure of the gut microbiota.

Keywords: Lactobacillus plantarum; intestinal barrier function; microbiota composition; suckling piglets.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus plantarumEnhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarumImproved Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarumImproved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarumImproved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarumReduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum 14DImproved Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum 14DImproved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum 14DImproved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum 14DReduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum 299vImproved Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum 299vImproved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum 299vImproved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum 299vReduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum DSM 6596Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum DSM 6596Enhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum DSM 6596Increased TLR ExpressionBeneficial
Moderate
Lactobacillus plantarum DSM 6596Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum HA-119Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum HA-119Enhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum HA-119Improved Immune ResponseBeneficial
Large
Lactobacillus plantarum HA-119Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum HA-119Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum KABP™-061Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum KABP™-061Enhanced Antimicrobial Peptide ExpressionBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Immune ResponseBeneficial
Large
Lactobacillus plantarum KABP™-061Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum KABP™-061Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum L-137Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum L-137Enhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum L-137Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum L-137Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum L-137Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum N13Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum N13Enhanced Antimicrobial Peptide ProductionBeneficial
Moderate
Lactobacillus plantarum N13Modulated Immune ResponseBeneficial
Moderate
Lactobacillus plantarum N13Reduced Incidence of DiarrheaBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum Rosell-1012Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Increased Abundance of Antimicrobial Peptide mRNABeneficial
Moderate
Lactobacillus plantarum Rosell-1012Increased mRNA Abundance of Toll-like ReceptorsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum Rosell-AAltered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum Rosell-AEnhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum Rosell-AReduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum SD-5209Altered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum SD-5209Improved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum SD-5209Improved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum SD-5209Reduced Diarrhea IncidenceBeneficial
Moderate
Lactobacillus plantarum SD5209Enhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Improved Immune ResponseBeneficial
Large
Lactobacillus plantarum UALp-05MAltered Gut Microbiota CompositionBeneficial
Large
Lactobacillus plantarum UALp-05MEnhanced Antimicrobial Peptide LevelsBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Intestinal Barrier FunctionBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Intestinal MorphologyBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Diarrhea IncidenceBeneficial
Moderate
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