Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial
- 2019-04-11
- Nutrients 11(4)
- Yen-Wenn Liu
- M. Liong
- Y. Chung
- Hui-Yi Huang
- W. Peng
- Yun-Fang Cheng
- Yu-Siou Lin
- Yu-Yu Wu
- Y. Tsai
- PubMed: 30979038
- DOI: 10.3390/nu11040820
Abstract
This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.
Keywords: Lactobacillus plantarum PS128; anxiety; autism spectrum disorder (ASD); hyperactivity; psychobiotic.
Research Insights
Supplement | Health Outcome | Effect Type | Effect Size |
---|---|---|---|
Lactobacillus Bulgaricus & Lactobacillus Plantarum | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus Bulgaricus & Lactobacillus Plantarum | Notable Improvement in Multiple Health Metrics | Beneficial | Moderate |
Lactobacillus genseni | Improved SNAP-IV Scores | Beneficial | Moderate |
Lactobacillus genseni | Improved Specific Elements of ASD Behaviors | Beneficial | Moderate |
Lactobacillus plantarum | Improved Behavioral Elements | Beneficial | Small |
Lactobacillus plantarum | Improved SNAP-IV Total Score for Children Aged 7-12 | Beneficial | Moderate |
Lactobacillus plantarum | Reduced Oppositional/Defiant Behaviors | Beneficial | Moderate |
Lactobacillus plantarum 14D | Improved SNAP-IV Total Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum 14D | Improved Various Elements | Beneficial | Moderate |
Lactobacillus plantarum 14D | Reduced Oppositional/Defiant Behaviors | Beneficial | Moderate |
Lactobacillus plantarum DSM 6595 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum DSM 6595 | Improved SNAP-IV Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum DSM 6596 | Improved ASD Symptoms | Beneficial | Moderate |
Lactobacillus plantarum DSM 6596 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum DSM 6596 | Improved SNAP-IV Total Score | Beneficial | Moderate |
Lactobacillus plantarum HA-119 | Improved General Behavioral Scores | Beneficial | Moderate |
Lactobacillus plantarum HA-119 | Reduced Oppositional/Defiant Behaviors | Beneficial | Moderate |
Lactobacillus plantarum KABP™-061 | Improved ASD Symptoms | Beneficial | Moderate |
Lactobacillus plantarum KABP™-061 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum KABP™-061 | Improved SNAP-IV Total Score for Children Aged 7-12 | Beneficial | Moderate |
Lactobacillus plantarum Lp-115 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum Lp-115 | Improved SNAP-IV Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum Lp-115 | Improved Specific Elements Within Assessed Measures | Beneficial | Small |
Lactobacillus plantarum N13 | Improved Behavioral Health | Beneficial | Moderate |
Lactobacillus plantarum R1012 | Improved ASD Symptoms | Beneficial | Moderate |
Lactobacillus plantarum R1012 | Improved Behavioral Symptoms in Younger Children | Beneficial | Moderate |
Lactobacillus plantarum R1012 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum Rosell-1012 | Improved Autism Behavioral Scores | Beneficial | Small |
Lactobacillus plantarum Rosell-1012 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum Rosell-A | Improved SNAP-IV Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum Rosell-A | Improved Secondary Symptoms | Beneficial | Moderate |
Lactobacillus plantarum Rosell-A | Reduced Oppositional/Defiant Behaviors | Beneficial | Moderate |
Lactobacillus plantarum SD-5209 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum SD-5209 | Improved SNAP-IV Total Score for Children Aged 7-12 | Beneficial | Moderate |
Lactobacillus plantarum SD-5209 | Notable Overall Improvement | Beneficial | Moderate |
Lactobacillus plantarum SD5209 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum SD5209 | Improved SNAP-IV Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum UALp-05 | Improved Behavioral Health | Beneficial | Moderate |
Lactobacillus plantarum UALp-05 | Improved Behavioral Symptoms in Younger Children | Beneficial | Moderate |
Lactobacillus plantarum UALp-05 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum UALp-05M | Improved Behavioral Elements | Beneficial | Small |
Lactobacillus plantarum UALp-05M | Improved Behavioral Symptoms in Younger Children | Beneficial | Moderate |
Lactobacillus plantarum UALp-05M | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum VPro 10 | Improved ASD Symptoms | Beneficial | Moderate |
Lactobacillus plantarum VPro 10 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum VPro 10 | Improved SNAP-IV Score for Younger Children | Beneficial | Large |
Lactobacillus plantarum WCFS1 | Improved Opposition and Defiance Behaviors | Beneficial | Moderate |
Lactobacillus plantarum WCFS1 | Improved SNAP-IV Total Score | Beneficial | Moderate |