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Effects of Lactobacillus plantarum PS128 on Children with Autism Spectrum Disorder in Taiwan: A Randomized, Double-Blind, Placebo-Controlled Trial

  • 2019-04-11
  • Nutrients 11(4)
    • Yen-Wenn Liu
    • M. Liong
    • Y. Chung
    • Hui-Yi Huang
    • W. Peng
    • Yun-Fang Cheng
    • Yu-Siou Lin
    • Yu-Yu Wu
    • Y. Tsai

Abstract

This four-week, randomized, double-blind, placebo-controlled study investigated the effects of Lactobacillus plantarum PS128 (PS128) on boys with autism spectrum disorder (ASD) aged 7-15 in Taiwan. All subjects fulfilled the criteria for ASD diagnosis of DSM-V and the Autism Diagnostic Interview-Revised (ADI-R). Questionnaires used for the primary outcome measure include the Autism Behavior Checklist-Taiwan version (ABC-T), the Social Responsiveness Scale (SRS) and the Child Behavior Checklist (CBCL). The Swanson, Nolan, and Pelham-IV-Taiwan version (SNAP-IV) and the Clinical Global Impression-improvement (CGI-I) were used for the secondary outcome measure. The results showed that PS128 ameliorated opposition/defiance behaviors, and that the total score of SNAP-IV for younger children (aged 712) improved significantly compared with the placebo group. Additionally, several elements were also notably improved in the PS128 group after 28-day consumption of PS128. Further studies are needed to better clarify the effects of PS128 for younger children with ASD on broader symptoms.

Keywords: Lactobacillus plantarum PS128; anxiety; autism spectrum disorder (ASD); hyperactivity; psychobiotic.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus Bulgaricus & Lactobacillus PlantarumImproved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus Bulgaricus & Lactobacillus PlantarumNotable Improvement in Multiple Health MetricsBeneficial
Moderate
Lactobacillus genseniImproved SNAP-IV ScoresBeneficial
Moderate
Lactobacillus genseniImproved Specific Elements of ASD BehaviorsBeneficial
Moderate
Lactobacillus plantarumImproved Behavioral ElementsBeneficial
Small
Lactobacillus plantarumImproved SNAP-IV Total Score for Children Aged 7-12Beneficial
Moderate
Lactobacillus plantarumReduced Oppositional/Defiant BehaviorsBeneficial
Moderate
Lactobacillus plantarum 14DImproved SNAP-IV Total Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum 14DImproved Various ElementsBeneficial
Moderate
Lactobacillus plantarum 14DReduced Oppositional/Defiant BehaviorsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum DSM 6595Improved SNAP-IV Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum DSM 6596Improved ASD SymptomsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum DSM 6596Improved SNAP-IV Total ScoreBeneficial
Moderate
Lactobacillus plantarum HA-119Improved General Behavioral ScoresBeneficial
Moderate
Lactobacillus plantarum HA-119Reduced Oppositional/Defiant BehaviorsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved ASD SymptomsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum KABP™-061Improved SNAP-IV Total Score for Children Aged 7-12Beneficial
Moderate
Lactobacillus plantarum Lp-115Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum Lp-115Improved SNAP-IV Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum Lp-115Improved Specific Elements Within Assessed MeasuresBeneficial
Small
Lactobacillus plantarum N13Improved Behavioral HealthBeneficial
Moderate
Lactobacillus plantarum R1012Improved ASD SymptomsBeneficial
Moderate
Lactobacillus plantarum R1012Improved Behavioral Symptoms in Younger ChildrenBeneficial
Moderate
Lactobacillus plantarum R1012Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum Rosell-1012Improved Autism Behavioral ScoresBeneficial
Small
Lactobacillus plantarum Rosell-1012Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Secondary SymptomsBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved SNAP-IV Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Oppositional/Defiant BehaviorsBeneficial
Moderate
Lactobacillus plantarum SD5209Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum SD5209Improved SNAP-IV Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum SD-5209Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum SD-5209Improved SNAP-IV Total Score for Children Aged 7-12Beneficial
Moderate
Lactobacillus plantarum SD-5209Notable Overall ImprovementBeneficial
Moderate
Lactobacillus plantarum UALp-05Improved Behavioral HealthBeneficial
Moderate
Lactobacillus plantarum UALp-05Improved Behavioral Symptoms in Younger ChildrenBeneficial
Moderate
Lactobacillus plantarum UALp-05Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Behavioral ElementsBeneficial
Small
Lactobacillus plantarum UALp-05MImproved Behavioral Symptoms in Younger ChildrenBeneficial
Moderate
Lactobacillus plantarum UALp-05MImproved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum VPro 10Improved ASD SymptomsBeneficial
Moderate
Lactobacillus plantarum VPro 10Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum VPro 10Improved SNAP-IV Score for Younger ChildrenBeneficial
Large
Lactobacillus plantarum WCFS1Improved Opposition and Defiance BehaviorsBeneficial
Moderate
Lactobacillus plantarum WCFS1Improved SNAP-IV Total ScoreBeneficial
Moderate

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