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Effects of perilla seed oil supplementation on leukotriene generation by leucocytes in patients with asthma associated with lipometabolism.

  • 2000
  • International archives of allergy and immunology 122(2)
    • M Okamoto
    • F Mitsunobu
    • K Ashida
    • T Mifune
    • Y Hosaki
    • H Tsugeno
    • S Harada
    • Y Tanizaki
    • M Kataoka
    • K Niiya
    • M Harada

Study Design

Type
Clinical Trial
Population
patients with asthma
Methods
dietary perilla seed oil (n-3 fatty acids) supplementation; comparison of groups based on suppression of leukotriene C4 generation by leucocytes
Duration
4 weeks
Funding
Unclear

Background

Dietary sources of alpha-linolenic acid, such as perilla seed oil, may have the capacity to inhibit the generation of leukotrienes (LTs) by leucocytes in patients with asthma, as has been reported with the consumption of other long-chain n-3 fatty acids.

Methods

The factors affecting the suppression of leukotriene (LT) C4 generation by leucocytes were examined by comparing the clinical features of patients with asthma who had been given dietary perilla seed oil (n-3 fatty acids). Group A consisted of patients in whom the leucocyte generation of LTC4 was suppressed by dietary perilla seed oil. Group B consisted of those in whom LTC4 generation was not suppressed.

Results

LTC4 generation by leucocytes decreased significantly in group A after 2 (p < 0.05) and 4 weeks (p < 0.05); conversely, it increased significantly in group B after 4 weeks (p < 0.05). The two study groups differed significantly in terms of LTC4 generation by leucocytes after 4 weeks of dietary supplementation (p < 0.05). Ventilatory parameters such as peak expiratory flow (PEF), forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV(1)) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05). Values of PEF, FVC, FEV(1) and maximum expiratory flow at 25% of the forced vital capacity (V(25)) differed significantly between groups A and B prior to dietary supplementation. Serum levels of total cholesterol, low-density lipoprotein (LDL) cholesterol and phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks. Serum levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, LDL cholesterol and phospholipid differed significantly between the two study groups prior to dietary supplementation. Serum levels of triglyceride and LDL cholesterol differed significantly between the two study groups after 4 weeks of dietary supplementation.

Conclusions

Dietary supplementation with perilla seed oil in selected patients with asthma suppresses the generation of LTC4 and is associated with clinical features such as respiratory function and lipometabolism.

Research Insights

  • Perilla→Improved Forced Expiratory Volume in One Second

    forced expiratory volume in 1 s (FEV(1)) increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Improved Forced Vital Capacity

    forced vital capacity (FVC) ... increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Improved Peak Expiratory Flow

    Ventilatory parameters such as peak expiratory flow (PEF) ... increased significantly after 4 weeks of dietary supplementation in group A (p < 0.05)

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Reduced Blood Cholesterol

    Serum levels of total cholesterol ... were significantly decreased by dietary supplementation in group A after 4 weeks

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Reduced Leukotriene C4 Generation

    conversely, it increased significantly in group B after 4 weeks (p < 0.05)

    Effect
    Harmful
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Reduced Low-Density Lipoprotein Level

    Serum levels of ... low-density lipoprotein (LDL) cholesterol ... were significantly decreased by dietary supplementation in group A after 4 weeks

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
  • Perilla→Reduced Phospholipid Level

    Serum levels of ... phospholipid were significantly decreased by dietary supplementation in group A after 4 weeks

    Effect
    Beneficial
    Effect size
    Small
    Dose
    dietary supplementation (amount not specified)
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