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Effects of turmeric extract supplementation on the lipid and lipoprotein subfraction profile in hemodialysis patients: A randomised, double-blind, crossover and controlled trial.

  • 2023-04-12
  • Phytotherapy research : PTR 37(8)
    • L Alvarenga
    • L F M F Cardozo
    • M Ribeiro-Alves
    • N R T Damasceno
    • A A Berretta
    • J A Lima
    • P Khosla
    • D Fouque
    • D Mafra

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 11
Population
hemodialysis (HD) patients
Methods
longitudinal, double-blind, washout-period randomized clinical trial; patients randomized to curcumin group (orange and carrot juice with 2.5 g of Curcuma Longa extract) or control group (juice without curcumin) 3x/w during HD sessions for 3 months, then crossover after washout
Blinding
Double-blind
Duration
3 months
Dyslipidemia is common in patients with chronic kidney disease. Curcumin, a bioactive polyphenol from Curcuma longa, can improve lipid profile. This study aims to analyze the effects of Curcuma Longa extract supplementation on lipid profile and lipoprotein subfractions in hemodialysis (HD) patients. This is a longitudinal, double-blind, washout-period randomized clinical trial. The patients were randomized into two groups: the curcumin group (n = 10) (orange and carrot juice with 2.5 g of Curcuma Longa extract) and the control group (n = 11) (juice without curcumin) 3x/w during HD sessions for 3 months. After the washout period, patients continued the supplementation as a crossover for the same period. The lipid profile was measured using enzymatic assays. The high-density lipoprotein and low-density lipoprotein subfractions analyses were performed using LipoprintTM. In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post-intervention for the control and curcumin groups of 38.5 (19.8) mg/dL (p = 0.06). There was no statistical difference in the others parameters. In conclusion, Curcuma longa extract may be a good nutritional strategy to reduce triglyceride plasma levels in hemodialysis patients, but it seems ineffective for the other parameter.

Research Insights

  • Turmeric→Improved Lipoprotein Subfraction Profile

    The high-density lipoprotein and low-density lipoprotein subfractions analyses were performed using LipoprintTM. ... There was no statistical difference in the others parameters.

    Effect
    Neutral
    Effect size
    Small
    Dose
    2.5 g of Curcuma Longa extract per session, 3 times per week
  • Turmeric→Increased HDL Cholesterol Levels

    There was no statistical difference in the others parameters.

    Effect
    Neutral
    Effect size
    Small
    Dose
    2.5 g of Curcuma Longa extract per session, 3 times per week
  • Turmeric→Reduced Low-Density Lipoprotein Level

    There was no statistical difference in the others parameters.

    Effect
    Neutral
    Effect size
    Small
    Dose
    2.5 g of Curcuma Longa extract per session, 3 times per week
  • Turmeric→Reduced Total Cholesterol Levels

    There was no statistical difference in the others parameters.

    Effect
    Neutral
    Effect size
    Small
    Dose
    2.5 g of Curcuma Longa extract per session, 3 times per week
  • Turmeric→Reduced Triglyceride Levels

    In the curcumin group, the triglyceride values tended to decrease with a different triglyceride variation between the pre and post-intervention for the control and curcumin groups of 38.5 (19.8) mg/dL (p = 0.06).

    Effect
    Neutral
    Effect size
    Small
    Dose
    2.5 g of Curcuma Longa extract per session, 3 times per week
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