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Effects of Whole Milk Supplementation on Gut Microbiota and Cardiometabolic Biomarkers in Subjects with and without Lactose Malabsorption.

  • 2018-10-02
  • Nutrients 10(10)
    • Xiaoqin Li
    • Jiawei Yin
    • Yalun Zhu
    • Xiaoqian Wang
    • Xiaoli Hu
    • Wei Bao
    • Yue Huang
    • Liangkai Chen
    • Sijing Chen
    • Wei Yang
    • Zhilei Shan
    • Liegang Liu

Study Design

Type
Clinical Trial
Population
31 LM and 31 LA, 1:1 matched by age, sex, body mass index, and daily dairy intake
Methods
pair-wise intervention study, 250 mL/day whole milk for four weeks
Blinding
Open-label
Duration
four weeks
Funding
Unclear
  • Rigorous Journal
The aim of this study was to compare the impact of whole milk supplementation on gut microbiota and cardiometabolic biomarkers between lactose malabsorbers (LM) and absorbers (LA). We performed a pair-wise intervention study of 31 LM and 31 LA, 1:1 matched by age, sex, body mass index, and daily dairy intake. Subjects were required to add 250 mL/day whole milk for four weeks in their routine diet. At the beginning and the end of the intervention period, we collected data on gut microbiota and cardiometabolic biomarkers. Whole milk supplementation significantly increased Actinobacteria (P < 0.01), Bifidobacterium (P < 0.01), Anaerostipe (P < 0.01), and Blautia (P = 0.04), and decreased Megamonas (P = 0.04) in LM, but not LA. Microbial richness and diversity were not affected. The fecal levels of short-chain fatty acids (SCFAs) remained stable throughout the study. Body fat mass (P < 0.01) and body fat percentage (P < 0.01) reduced in both groups, but the changes did not differ between groups. No significant differences in other cardiometabolic markers were found between LM and LA. When compared with LA, whole milk supplementation could alter the intestinal microbiota composition in LM, without significant changes in fecal SCFAs and cardiometabolic biomarkers.

Research Insights

  • Whole Milk→Changed Short-Chain Fatty Acid Level

    The fecal levels of short-chain fatty acids (SCFAs) remained stable throughout the study.

    Effect
    Neutral
    Effect size
    Small
    Dose
    250 mL/day
  • Whole Milk→Reduced Body Fat Mass

    Body fat mass (P < 0.01) and body fat percentage (P < 0.01) reduced in both groups, but the changes did not differ between groups.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mL/day
  • Whole Milk→Reduced Body Fat Percentage

    Body fat mass (P < 0.01) and body fat percentage (P < 0.01) reduced in both groups, but the changes did not differ between groups.

    Effect
    Beneficial
    Effect size
    Small
    Dose
    250 mL/day
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