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Efficacy and Safety of a Dual-Wavelength 589/1319 nm Laser for the Treatment of Acne Erythema: A Split-Face Randomized Controlled Trial.

  • 2026-05-01
  • Journal of cosmetic dermatology 25(5)
    • Suphagan Boonpethkaew
    • Pimsiri Anansiripun
    • Warittha Maitrisathit
    • Yanisa Ratanapokasatit
    • Sonphet Chirasuthat
    • Panrudee Wechsuruk
    • Penpun Wattanakrai

Study Design

Type
Randomized Controlled Trial (RCT)
Population
Thirty patients with bilateral acne erythema
Methods
One facial side received 6 sessions of 589/1319 nm SSDW laser treatment, while the contralateral side was treated with twice-daily Aloe vera gel for 18 weeks
Blinding
Open-label
Duration
18 weeks
Funding
Unclear

Background

The 589/1319 nm solid-state dual-wavelength (SSDW) laser, which targets cutaneous vasculature, may be an effective treatment for acne erythema (AE).

Objectives

To compare the efficacy and safety of the 589/1319 nm SSDW laser with topical soothing Aloe vera (AV) gel for the treatment of AE.

Patients and methods

Thirty patients with bilateral AE were enrolled. One facial side received 6 sessions of 589/1319 nm SSDW laser treatment, while the contralateral side was treated with twice-daily AV gel for 18 weeks. Patients were followed for 8 weeks after the final laser session. AE severity, acne severity, and adverse events were assessed.

Results

Twenty-nine patients completed the study. Both treatment modalities significantly reduced AE. The laser-treated side demonstrated a faster clinical response, with a significant reduction compared to baseline at 2 weeks, whereas AV gel required 4 weeks to achieve a comparable effect (within-group p < 0.05; no between-group difference). At the 8-week follow-up, the response rate was 72% for the laser-treated sides and 69% for the AV-treated sides. AE improvement correlated with reductions in acne severity in the laser-treated sides (rs = 0.47, p = 0.03). Patients reported higher satisfaction with laser treatment up to 4 weeks after the final laser session. Average pain score for the laser treatment was 1.52 out of 10. No serious adverse events were observed.

Conclusions

The 589/1319 nm SSDW laser may be an effective early adjunctive treatment for acne erythema, offering minimal discomfort with no downtime and may additionally improve acne severity.

Research Insights

  • Aloe→Reduced Acne Erythema

    Both treatment modalities significantly reduced AE. The laser-treated side demonstrated a faster clinical response, with a significant reduction compared to baseline at 2 weeks, whereas AV gel required 4 weeks to achieve a comparable effect (within-group p < 0.05; no between-group difference). At the 8-week follow-up, the response rate was 72% for the laser-treated sides and 69% for the AV-treated sides.

    Effect
    Beneficial
    Effect size
    Small

Adverse Events Reported

  • Aloe→Overall tolerability

    No serious adverse events were observed.

    Finding
    No significant difference
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