Efficacy of Cuminum Cyminum supplementation on lipid profile and anthropometric parameters: A systematic review and meta-analysis of randomized controlled clinical trials.

2021-11-25
Phytotherapy research : PTR 36(1)
- Omid Mohammad Tavakoli-Rouzbehani
- Amir Hossein Faghfouri
- Maryam Anbari
- Omid Nikpayam
- Hadi PourMirzaei Olyaei
- Mohammad Alizadeh

PubMed: 34825421
DOI: 10.1002/ptr.7327

Study Design

Type: Meta-Analysis
Methods: PubMed, Scopus, Web of Science, and Embase databases were systematically searched until May 2021. The random-effect model was used to study the effect sizes. Subgroup analysis and meta-regression were used to assess heterogeneity. Publication bias was studied by funnel plots. GRADE approach was used to assess quality of evidence.

We aimed to evaluate the effect of Cuminum Cyminum (CC) supplementation on lipid profile and selected anthropometric parameters. PubMed, Scopus, Web of Science, and Embase databases were systematically searched until May 2021. The random-effect model was used to study the effect sizes. The sources of heterogeneity were assessed using subgroup analysis and meta-regression. Publication bias was studied by funnel plots. The GRADE approach was used to assess the overall quality of the evidence.The data from our eight included studies have indicated that CC supplementation can lower body mass index (BMI) (WMD = -0.88 kg/m² ; 95%CI: -1.58, -0.18; p = .023) and total cholesterol (TC) (WMD = -3.96 mg/dl; 95%CI: -6.51, -1.04; p=.008). Also, after adjusting for publication bias, CC was shown to be effective in improving waist circumference (WC), high-density lipoprotein (HDL-C), and triglycerides (TG) levels. Although, the current evidence has not shown that CC supplementation can affect low-density lipoprotein (LDL-C), our subgroup analysis has indicated that CC supplementation with supplementation length of more than 8 weeks is associated with beneficial effects on LDL-C.While CC might be a suitable choice in managing BMI and TC, further high-quality studies are needed to confirm its efficacy in the clinical setting.

Research Insights

Cumin→Improved High-Density Lipoprotein Level
after adjusting for publication bias, CC was shown to be effective in improving ... high-density lipoprotein (HDL-C)
Effect
Neutral
Effect size
Small
Cumin→Reduced Blood Cholesterol
CC supplementation can lower ... total cholesterol (TC) (WMD = -3.96 mg/dl; 95%CI: -6.51, -1.04; p=.008)
Effect
Beneficial
Effect size
Small
Cumin→Reduced Body Mass Index
CC supplementation can lower body mass index (BMI) (WMD = -0.88 kg/m²; 95%CI: -1.58, -0.18; p = .023)
Effect
Beneficial
Effect size
Moderate
Cumin→Reduced Low-Density Lipoprotein Level
the current evidence has not shown that CC supplementation can affect low-density lipoprotein (LDL-C)
Effect
Neutral
Effect size
Small
Cumin→Reduced Triglyceride Levels
after adjusting for publication bias, CC was shown to be effective in improving ... triglycerides (TG) levels
Effect
Neutral
Effect size
Small
Cumin→Reduced Waist Circumference
after adjusting for publication bias, CC was shown to be effective in improving waist circumference (WC)
Effect
Neutral
Effect size
Small