Evaluating the effects of seed oils on lipid profile, inflammatory and oxidative markers, and glycemic control of diabetic and dyslipidemic patients: a systematic review of clinical studies.

2025-02-07
Frontiers in nutrition 12
- Lucas Fornari Laurindo
- Lívia Fornari Laurindo
- Victória Dogani Rodrigues
- Jéssica da Silva Camarinha Oliveira
- Beatriz Leme Boaro
- Adriano Cressoni Araújo
- Elen Landgraf Guiguer
- Claudia Rucco Penteado Detregiachi
- Virgínia Maria Cavallari Strozze Catharin
- Eduardo Federighi Baisi Chagas
- Vitor Cavallari Strozze Catharin
- Rosa Direito
- Sandra Maria Barbalho

PubMed: 39996006
DOI: 10.3389/fnut.2025.1502815

Study Design

Type: Systematic Review
Population: patients with diabetes and dyslipidemia
Methods: A comprehensive search across databases identified studies focusing on the effects of seed oils; studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and open-label studies

Diabetes mellitus and dyslipidemia are significant health concerns that elevate the risk of cardiovascular disease and other metabolic disorders, necessitating effective management strategies. Recent research has highlighted the potential role of dietary fats, particularly seed oils, in influencing health outcomes in these conditions. This systematic review evaluates the impact of seed oils on lipid profiles, inflammatory and oxidative markers, and glycemic control in patients with diabetes and dyslipidemia. A comprehensive search across databases, including PubMed, Scopus, Web of Science, Cochrane Library, and Google Scholar, identified studies focusing on the effects of seed oils. The studies include randomized controlled, parallel-design, double-blind, placebo-controlled, and open-label studies published in English. The quality of the studies was assessed through a detailed review process, and data were extracted to evaluate the effects of seed oils on key metabolic markers. The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers. The findings suggest that seed oils may benefit in managing diabetes and dyslipidemia, although the results are sometimes inconsistent. This review provides valuable insights for dietary recommendations and therapeutic strategies, highlighting the need for further research to clarify the role of seed oils in metabolic health.

Research Insights

Flax→Improved Blood Lipid Profile
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Moderate
Dose
specified in individual studies (abstract does not provide exact dose)
Flax→Improved Glycemia
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Moderate
Dose
specified in individual studies (abstract does not provide exact dose)
Flax→Reduced Oxidative Stress Marker Level
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Small
Dose
specified in individual studies (abstract does not provide exact dose)
Sesame→Improved Blood Lipid Profile
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Moderate
Dose
specified in individual studies (abstract does not provide exact dose)
Sesame→Improved Glycemia
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Moderate
Dose
specified in individual studies (abstract does not provide exact dose)
Sesame→Reduced Oxidative Stress Marker Level
The review included 11 studies demonstrating that seed oils derived from canola, flaxseed, and sesame seeds can positively influence lipid profiles and glycemic control while potentially modulating oxidative stress markers.
Effect
Beneficial
Effect size
Small
Dose
specified in individual studies (abstract does not provide exact dose)