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Evaluation of antioxidative and diabetes-preventive properties of an ancient grain, KAMUT® khorasan wheat, in healthy volunteers.

  • 2017-11-16
  • European journal of nutrition 58(1)
    • Caterina Trozzi
    • Francesca Raffaelli
    • Arianna Vignini
    • Laura Nanetti
    • Rosaria Gesuita
    • Laura Mazzanti

Study Design

Type
Randomized Controlled Trial (RCT)
Sample size
n = 30
Population
30 healthy volunteers
Methods
randomized, non-blind, parallel arm study where the biochemical parameters of volunteers with a diet based on organic whole grain KAMUT® khorasan products, as the only source of cereal products were compared to a similar replacement diet based on organic whole grain modern durum wheat products
Blinding
Open-label
Duration
16 weeks
Funding
Unclear
  • Rigorous Journal

Purpose

Recently, there was an increasing interest on the use of ancient grains because of their better health-related composition. The aim of this study was to evaluate in healthy human subjects the antioxidative and diabetes-preventive properties of ancient KAMUT® khorasan wheat compared to modern wheat.

Methods

The study was a randomized, non-blind, parallel arm study where the biochemical parameters of volunteers with a diet based on organic whole grain KAMUT® khorasan products, as the only source of cereal products were compared to a similar replacement diet based on organic whole grain modern durum wheat products. A total of 30 healthy volunteers were recruited and the intervention period lasted 16 weeks. Blood analyses were performed before and after the diet intervention. The effect of KAMUT® khorasan products on biochemical parameters was analyzed by multiple quantile regression adjusted for age, sex, physical activity and BMI compared to data at baseline.

Results

Subjects receiving KAMUT® khorasan products showed a significantly greater decrease of fat mass (b = 3.7%; CI 1.6-5.5; p = 0.042), insulin (b = 2.4 µU/ml; CI 0.2-4.2; p = 0.036) and a significant increase of DHA (b = - 0.52%; CI - 1.1 to - 0.12; p = 0.021).

Conclusions

Our study provides evidence that a substitution diet with KAMUT® khorasan wheat products can reduce some markers associated to the development of type-2 diabetes compared to a diet of modern wheat.

Research Insights

  • Khorasan wheat→Improved Insulin Levels

    Subjects receiving KAMUT® khorasan products showed a significantly greater decrease of ... insulin (b = 2.4 µU/ml; CI 0.2-4.2; p = 0.036)

    Effect
    Beneficial
    Effect size
    Small
  • Khorasan wheat→Increased DHA Level

    Subjects receiving KAMUT® khorasan products showed ... a significant increase of DHA (b = - 0.52%; CI - 1.1 to - 0.12; p = 0.021)

    Effect
    Beneficial
    Effect size
    Small
  • Khorasan wheat→Reduced Body Fat Mass

    Subjects receiving KAMUT® khorasan products showed a significantly greater decrease of fat mass (b = 3.7%; CI 1.6-5.5; p = 0.042)

    Effect
    Beneficial
    Effect size
    Small
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