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Flaxseed Improves Glucose and Lipid Metabolism in Mexican Subjects with Type 2 Diabetes: A Parallel Randomized Clinical Trial.

  • 2025-02-17
  • Nutrients 17(4)
    • Sabina López-Toledo
    • María Cruz Pineda De la Cruz
    • Itzae Adonai Gutiérrez-Hurtado
    • Ana L Gijón-Soriano
    • Enrique Martínez-Martínez
    • Carlos Valencia-Santiago
    • José E Orellana-Centeno
    • Sergio A Ramírez-García
    • Royer Pacheco-Cruz

Study Design

Type
Randomized Controlled Trial (RCT)
Population
adult patients with Type 2 diabetes in Oaxaca, Mexico
Methods
Participants were recruited and randomized into clinical trials between April and June 2023; consuming 16 g of flaxseed daily for three months
Duration
three months
Funding
Unclear
  • Rigorous Journal

Introduction

Type 2 diabetes is a significant health concern in the 21st century, and its prevalence continues to rise despite efforts to promote preventive lifestyle changes. This increase has led to higher economic burdens, prompting the search for non-pharmacological methods to manage glucose levels.

Objective

To assess the effects of flaxseed consumption on biochemical markers (glucose, glycated hemoglobin, total cholesterol, and triglycerides) in adult patients with Type 2 diabetes in Oaxaca, Mexico.

Materials and methods

Participants were recruited and randomized into clinical trials between April and June 2023, and the study protocol was approved by a Human Research Ethics Committee.

Results

Consuming 16 g of flaxseed daily for three months led to a significant decrease in glucose, total cholesterol, and triglyceride levels (p < 0.001) in Type 2 diabetes patients in the intervention group (n = 82). Belonging to the control group (n = 84) was correlated with presenting higher levels of glycated hemoglobin (Spearman's Rho 0.640; p < 0.001), higher levels of glucose (Spearman's Rho 0.352; p < 0.001), total cholesterol (Spearman's Rho 0.796; p < 0.001), and triglycerides (Spearman's Rho 0.700; p < 0.001).

Conclusions

A daily intake of 16 g of flaxseed is an effective supplementary treatment for adult Mexican patients with Type 2 diabetes, as evidenced by reduced levels of glycated hemoglobin, glucose, cholesterol, and triglycerides in the intervention group. Potential implications for clinical practice: Healthcare providers may consider recommending flaxseed in the diets of patients with obesity, prediabetes, or Type 2 diabetes to improve glucose and lipid metabolism and overall metabolic health.

Research Insights

  • flaxseed→Reduced Blood Cholesterol

    Consuming 16 g of flaxseed daily for three months led to a significant decrease in... total cholesterol... levels (p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    16 g daily
  • flaxseed→Reduced Fasting Blood Glucose Levels

    Consuming 16 g of flaxseed daily for three months led to a significant decrease in glucose... levels (p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    16 g daily
  • flaxseed→Reduced Glycated Hemoglobin

    reduced levels of glycated hemoglobin, glucose, cholesterol, and triglycerides in the intervention group

    Effect
    Beneficial
    Effect size
    Large
    Dose
    16 g daily
  • flaxseed→Reduced Triglyceride Levels

    Consuming 16 g of flaxseed daily for three months led to a significant decrease in... triglyceride levels (p < 0.001)

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    16 g daily
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