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Habitual Coffee Consumption and Systemic Health Outcomes: A Comprehensive Review.

  • 2025-12-13
  • Cureus 17(12)
    • Eliza Kwapien
    • Mateusz Piszka
    • Filip Czarnecki
    • Marceli Mesyasz
    • Aleksandra Owczarska
    • Hubert Dacyl
    • Jan Banach
    • Wiktoria Z Kasprzyk
    • Jan K Luczak
    • Jakub Bartkowski

Study Design

Type
Review
This review analyzes extensive scientific data linking habitual coffee consumption to a wide range of physiological outcomes and divides them into cardiovascular, metabolic, and organ-specific effects. Unlike previous assumptions, moderate coffee intake positively affects many aspects of the health of the adult population. We can observe beneficial effects that translate into patients' longevity as well as reduced risks of chronic diseases. After analyzing the studies, the most significant protective associations were identified in the cardiovascular system, where moderate consumption (three to four cups daily, corresponding to approximately 450-600 mL of coffee) correlates with reduced all-cause and cardiovascular mortality, and a lower risk of heart failure. Many studies have highlighted the chemo-preventive potential of coffee constituents, indicating a reduced risk of specific malignancies, including liver and prostate cancer. The health consequences that manifest themselves clinically also include improved metabolic homeostasis, specifically a lower incidence of type 2 diabetes mellitus and liver fibrosis. This impact also extends to the central nervous system, where there is a clear correlation between caffeine intake and neuroprotection against neurodegenerative disorders such as Alzheimer's and Parkinson's disease. Evidence indicates a "J-shaped" relationship in many cases, suggesting that moderate intake is optimal. Conversely, supraphysiological consumption can induce transient hemodynamic disturbances, and unfiltered preparations may negatively impact lipid profiles due to higher diterpene content. Furthermore, evidence supports a linear dose-response relationship between caffeine intake and adverse pregnancy outcomes, specifically pregnancy loss, highlighting the need for strict caution in prenatal care. Due to the proven bioactive properties of compounds like chlorogenic acid and caffeine, updated public health perspectives are needed to recognize coffee not merely as a stimulant, but as a functional dietary component that promotes a healthy lifestyle, which will translate into the reduced burden of non-communicable diseases in the future.

Research Insights

  • Coffee→Increased Hemodynamic Disturbance

    supraphysiological consumption can induce transient hemodynamic disturbances

    Effect
    Harmful
    Effect size
    Small
    Dose
    supraphysiological consumption
  • Coffee→Reduced All-Cause Mortality

    moderate consumption (three to four cups daily, corresponding to approximately 450-600 mL of coffee) correlates with reduced all-cause and cardiovascular mortality

    Effect
    Beneficial
    Effect size
    Small
    Dose
    three to four cups daily, corresponding to approximately 450-600 mL of coffee
  • Coffee→Reduced Alzheimer Disease Risk

    neuroprotection against neurodegenerative disorders such as Alzheimer's and Parkinson's disease

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
  • Coffee→Reduced Cardiovascular Mortality

    moderate consumption (three to four cups daily, corresponding to approximately 450-600 mL of coffee) correlates with reduced all-cause and cardiovascular mortality

    Effect
    Beneficial
    Effect size
    Small
    Dose
    three to four cups daily, corresponding to approximately 450-600 mL of coffee
  • Coffee→Reduced Heart Failure Risk

    lower risk of heart failure

    Effect
    Beneficial
    Effect size
    Small
    Dose
    three to four cups daily, corresponding to approximately 450-600 mL of coffee
  • Coffee→Reduced Liver Cancer Risk

    chemo-preventive potential of coffee constituents, indicating a reduced risk of specific malignancies, including liver and prostate cancer

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
  • Coffee→Reduced Liver Fibrosis

    improved metabolic homeostasis, specifically a lower incidence of type 2 diabetes mellitus and liver fibrosis

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
  • Coffee→Reduced Parkinson Disease Risk

    neuroprotection against neurodegenerative disorders such as Alzheimer's and Parkinson's disease

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
  • Coffee→Reduced Prostate Cancer Risk

    chemo-preventive potential of coffee constituents, indicating a reduced risk of specific malignancies, including liver and prostate cancer

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
  • Coffee→Reduced Type 2 Diabetes Mellitus Incidence

    improved metabolic homeostasis, specifically a lower incidence of type 2 diabetes mellitus

    Effect
    Beneficial
    Effect size
    Moderate
    Dose
    supraphysiological consumption
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