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Health-Promoting Properties of Lactobacillus helveticus

  • 2012
  • Frontiers in Microbiology 3
    • Valentina Taverniti
    • S. Guglielmetti

Abstract

Lactobacillus helveticus is an important industrial thermophilic starter that is predominantly employed in the fermentation of milk for the manufacture of several cheeses. In addition to its technological importance, a growing body of scientific evidence shows that strains belonging to the L. helveticus species have health-promoting properties. In this review, we synthesize the results of numerous primary literature papers concerning the ability of L. helveticus strains to positively influence human health. Several in vitro studies showed that L. helveticus possesses many common probiotic properties, such as the ability to survive gastrointestinal transit, adhere to epithelial cells, and antagonize pathogens. In vivo studies in murine models showed that L. helveticus could prevent gastrointestinal infections, enhance protection against pathogens, modulate host immune responses, and affect the composition of the intestinal microbiota. Interventional studies and clinical trials have also demonstrated a number of health-promoting properties of L. helveticus. Finally, several studies suggested that specific enzymatic activities of L. helveticus could indirectly benefit the human host by enhancing the bioavailability of nutrients, removing allergens and other undesired molecules from food, and producing bioactive peptides through the digestion of food proteins. In conclusion, this review demonstrates that in light of the scientific literature presented, L. helveticus can be included among the bacterial species that are generally considered to be probiotic.

Keywords: ACE inhibitory activity; Lactobacillus helveticus; Probiotic; host-bacteria cross-talk; immunomodulation.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticusAltered Intestinal Microbiota CompositionBeneficial
Moderate
Lactobacillus helveticusEnhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticusImproved BioavailabilityBeneficial
Moderate
Lactobacillus helveticusIncreased Production of Bioactive PeptidesBeneficial
Moderate
Lactobacillus helveticusModulated Host Immune ResponseBeneficial
Moderate
Lactobacillus helveticusReduced Gastrointestinal InfectionsBeneficial
Moderate
Lactobacillus helveticus L10Altered Intestinal Microbiota CompositionBeneficial
Moderate
Lactobacillus helveticus L10Enhanced Gastrointestinal SurvivalBeneficial
Moderate
Lactobacillus helveticus L10Enhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticus L10Improved ImmunomodulationBeneficial
Moderate
Lactobacillus helveticus L10Improved Iron AbsorptionBeneficial
Moderate
Lactobacillus helveticus L10Increased Adhesion to Epithelial CellsBeneficial
Moderate
Lactobacillus helveticus L10Increased Production of Bioactive PeptidesBeneficial
Moderate
Lactobacillus helveticus L10Reduced Gastrointestinal InfectionsBeneficial
Moderate
Lactobacillus helveticus LH76Enhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticus LH76Improved BioavailabilityBeneficial
Moderate
Lactobacillus helveticus LH76Increased Production of Bioactive PeptidesBeneficial
Moderate
Lactobacillus helveticus LH76Modulated Microbiota CompositionBeneficial
Moderate
Lactobacillus helveticus LH76Reduced Gastrointestinal InfectionsBeneficial
Moderate
Lactobacillus helveticus R0052Altered Intestinal Microbiota CompositionBeneficial
Moderate
Lactobacillus helveticus R0052Enhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticus R0052Improved BioavailabilityBeneficial
Moderate
Lactobacillus helveticus R0052Improved Gastrointestinal Transit SurvivalBeneficial
Moderate
Lactobacillus helveticus R0052Improved Vaginal Epithelial Cell AdherenceBeneficial
Moderate
Lactobacillus helveticus R0052Increased Production of Bioactive PeptidesBeneficial
Moderate
Lactobacillus helveticus R0052Modulated Host Immune ResponseBeneficial
Moderate
Lactobacillus helveticus R0052Reduced Gastrointestinal InfectionsBeneficial
Moderate
Lactobacillus helveticus R0052Reduced Pathogenic LoadBeneficial
Moderate
Lactobacillus helveticus Rosell-52Enhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved BioavailabilityBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Gastrointestinal HealthBeneficial
Moderate
Lactobacillus helveticus Rosell-52Modulated Host Immune ResponseBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDAltered Intestinal Microbiota CompositionBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDEnhanced Gastrointestinal SurvivalBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDEnhanced Nutrient BioavailabilityBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDEnhanced Pathogen ProtectionBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDIncreased Adhesion to Epithelial CellsBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDIncreased Production of Bioactive PeptidesBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDReduced Intestinal InfectionsBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDReduced Pathogen ActivityBeneficial
Moderate

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