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Heat-killed Lactobacillus helveticus improves mood states: a randomised, double-blind, placebo-controlled study.

  • 2023-04-14
  • Beneficial Microbes 14(2)
    • N. Mutoh
    • I. Kakiuchi
    • A. Hiraku
    • N. Iwabuchi
    • K. Kiyosawa
    • K. Igarashi
    • M. Tanaka
    • M. Nakamura
    • M. Miyasaka

Abstract

We investigated the effects of heat-killed Lactobacillus helveticus MCC1848 on daily mood states in healthy young adults. Participants (n=58) were randomised to receive heat-killed L. helveticus MCC1848 powder or placebo powder for 4 weeks. During the study period, adverse events were recorded in the participant diary. Mood states were assessed before and 2 and 4 weeks after initiation of the intervention. The primary outcomes were the shortened version of the Profile of Mood States 2 (POMS 2) scores. Secondary outcomes included other mood state (State-Trait Anxiety Inventory (STAI); visual analogue scale (VAS)), quality of life (acute form of the SF-36v2), sleep (Athens Insomnia Scale (AIS)) and fatigue (Chalder Fatigue Scale (CFS)) scores. Four weeks of heat-killed L. helveticus MCC1848 intake, compared to placebo, significantly improved the shortened version of the POMS 2 'friendliness' and the VAS 'relaxed' scores, which are two indicators of positive mood states. On the other hand, heat-killed L. helveticus MCC1848 intake had no significant effects on negative mood state items (e.g. anger, nervousness, confusion) assessed by the shortened version of the POMS 2, STAI and VAS. AIS and CFS scores also showed no significant differences. No adverse effects were observed with 4 weeks of heat-killed L. helveticus MCC1848 intake. These results suggest that daily consumption of heat-killed L. helveticus MCC1848 is safe and has the potential to improve positive mood states. UMIN Clinical Trial Registry: UMIN000043697.

Keywords: gut-brain axis; psychobiotics; psychological stress.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticusImproved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus HA-128Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus HA-128Improved RelaxationBeneficial
Moderate
Lactobacillus helveticus HA-128No Adverse Effects ObservedNeutral
Moderate
Lactobacillus helveticus HA-128No Change in Negative Mood StatesNeutral
Small
Lactobacillus helveticus HA-128No Change in Sleep QualityNeutral
Small
Lactobacillus helveticus HA-128No Significant Change in FatigueNeutral
Small
Lactobacillus helveticus HA-501Ensured Safety for Human ConsumptionBeneficial
Large
Lactobacillus helveticus HA-501Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus HA-501No Change in Negative Mood StatesNeutral
Small
Lactobacillus helveticus L10Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus L10No Adverse Health EffectsBeneficial
Moderate
Lactobacillus helveticus L10No Change in Negative Mood StatesNeutral
Small
Lactobacillus helveticus L10No Change in Sleep QualityNeutral
Small
Lactobacillus helveticus LH76Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus LH76No Adverse Effects ObservedNeutral
Moderate
Lactobacillus helveticus LH76No Significant Effect on Negative Mood StatesNeutral
Small
Lactobacillus helveticus R0052Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus R0052No Adverse Health EffectsBeneficial
Moderate
Lactobacillus helveticus R0052No Change in Negative Mood StatesNeutral
Small
Lactobacillus helveticus R0052No Change in Sleep QualityNeutral
Small
Lactobacillus helveticus Rosell-52Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Sleep QualityNeutral
Small
Lactobacillus helveticus Rosell-52Reduced Fatigue LevelsNeutral
Small
Lactobacillus helveticus Rosell-52Reduced Negative Mood StatesNeutral
Small
Lactobacillus helveticus Rosell-52 MEImproved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDNo Adverse Health EffectsBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDNo Change in Negative Mood StatesNeutral
Small
Lactobacillus helveticus Rosell-52NDNo Change in Sleep QualityNeutral
Small
Lactobacillus helveticus VPro 13Improved Positive Mood StatesBeneficial
Moderate
Lactobacillus helveticus VPro 13Improved Sleep QualityNeutral
Small
Lactobacillus helveticus VPro 13No Adverse Health EffectsBeneficial
Moderate
Lactobacillus helveticus VPro 13No Impact on FatigueNeutral
Small
Lactobacillus helveticus VPro 13No Impact on Negative Mood StatesNeutral
Small

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