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Immunostimulant properties of a cell wall-modified whole Saccharomyces cerevisiae strain administered by diet to seabream (Sparus aurata L.).

  • 2003-12
  • Veterinary Immunology and Immunopathology 96(3-4)
    • A. Rodríguez
    • A. Cuesta
    • J. Ortuño
    • M. Esteban
    • J. Meseguer

Abstract

The possible differences in the immunostimulant effects between whole wild Saccharomyces cerevisiae and a mutant strain (fks-1) administered in the diet to gilthead seabream (Sparus aurata L.) were studied. Fish were fed diets containing 0 (control) or 10 g whole wild yeast or fks-1 strain per kilogram feed for 2, 4 or 6 weeks. After each sampling, the innate humoral (complement, lysozyme and peroxidases) and cellular (intracellular peroxidases, phagocytosis, respiratory burst activity and cytotoxicity) responses were determined. Among the humoral responses, serum peroxidases and complement activity were significantly decreased after 6 weeks of feeding with the fks-1 strain-supplemented diet, while lysozyme activity increased after 2 and 4 weeks of feeding the fks-1 strain. Of the cellular responses studied, phagocytosis was increased to a significant degree at all the assayed times but only by the fks-1 strain-supplemented diet, while respiratory burst activity (after 4 weeks) and natural cytotoxicity (after 4 and 6 weeks) increased with either yeast strain. The intracellular peroxidase content was not affected by the dietary supplementation of either yeast strain. These results are discussed with a view to assessing the possible use of wild and/or mutant yeast strains for immunostimulant purposes in aquaculture.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Saccharomyces cerevisiaeEnhanced Natural Killer Cell Tumoricidal ActivityBeneficial
Moderate
Saccharomyces cerevisiaeEnhanced Phagocytic ActivityBeneficial
Large
Saccharomyces cerevisiaeIncreased Respiratory Burst ActivityBeneficial
Moderate
Saccharomyces cerevisiaeIncreased Serum Lysozyme ActivityBeneficial
Moderate
Saccharomyces cerevisiaeUnchanged Intracellular Peroxidase LevelsNeutral
Small

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