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Impacts of supplementation with milk proteins on inflammation: a systematic review and meta-analysis.

  • 2025-01-07
  • Inflammopharmacology 33(3)
    • Shooka Mohammadi
    • Damoon Ashtary-Larky
    • Milad Mehrbod
    • Narges Kouhi Sough
    • Hossein Salehi Omran
    • Sina Dolatshahi
    • Niusha Amirani
    • Omid Asbaghi

Study Design

Type
Meta-Analysis
Population
adults
Methods
systematic review and dose-response meta-analysis of randomized controlled trials (RCTs)

Background

Impacts of milk proteins (MPs) on inflammation are uncertain. The current systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) evaluated the effects of whey protein (WP), casein protein (CP), or MP supplementation on serum levels of cytokines and adipokines in adults.

Methods

A comprehensive search of various online databases was conducted to find appropriate clinical trials published until September 2024. A random-effect statistical model was implemented.

Results

The meta-analysis included 53 RCTs. It was indicated that MP supplements had no substantial effects on serum values of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), adiponectin, and leptin. However, there were statistically significant decreases in serum levels of interleukin-6 (IL-6) following supplementation with MP (weighted mean difference (WMD): - 0.25 pg/mL, 95% CI - 0.48, - 0.03; P = 0.026) in the intervention group compared with the control group.

Conclusion

This study revealed that MP supplementation may not have any considerable impacts on the levels of cytokines and adipokines.

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