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Influence of 2 Weeks of Mango Ingestion on Inflammation Resolution after Vigorous Exercise.

  • 2023-12-21
  • Nutrients 16(1)
    • Camila A Sakaguchi
    • David C Nieman
    • Ashraf M Omar
    • Renee C Strauch
    • James C Williams
    • Mary Ann Lila
    • Qibin Zhang

Study Design

Type
Randomized Controlled Trial (RCT)
Population
22 cyclists
Methods
randomized crossover trial, 330 g mango/day with 0.5 L water or 0.5 L water alone for 2 weeks, followed by a 2.25 h cycling bout challenge
Duration
2 weeks
  • Rigorous Journal
Mangoes have a unique nutrient profile (carotenoids, polyphenols, sugars, and vitamins) that we hypothesized would mitigate post-exercise inflammation. This study examined the effects of mango ingestion on moderating exercise-induced inflammation in a randomized crossover trial with 22 cyclists. In random order with trials separated by a 2-week washout period, the cyclists ingested 330 g mango/day with 0.5 L water or 0.5 L of water alone for 2 weeks, followed by a 2.25 h cycling bout challenge. Blood and urine samples were collected pre- and post-2 weeks of supplementation, with additional blood samples collected immediately post-exercise and 1.5-h, 3-h, and 24 h post-exercise. Urine samples were analyzed for targeted mango-related metabolites. The blood samples were analyzed for 67 oxylipins, which are upstream regulators of inflammation and other physiological processes. After 2 weeks of mango ingestion, three targeted urine mango-related phenolic metabolites were significantly elevated compared to water alone (interaction effects, p ≤ 0.003). Significant post-exercise increases were measured for 49 oxylipins, but various subgroup analyses showed no differences in the pattern of change between trials (all interaction effects, p > 0.150). The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites.

Research Insights

  • mango→Reduced Exercise-Induced Inflammation

    The 2.25 h cycling bouts induced significant inflammation, but no countermeasure effect was found after 2 weeks of mango ingestion despite the elevation of mango gut-derived phenolic metabolites.

    Effect
    Neutral
    Effect size
    Small
    Dose
    330 g/day
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