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Lactobacillus casei improves resistance to pneumococcal respiratory infection in malnourished mice.

  • 2005-06
  • The Journal of Nutrition 135(6)
    • J. Villena
    • S. Racedo
    • Graciela Agüero
    • E. Bru
    • M. Medina
    • S. Alvarez

Abstract

We studied the effect of Lactobacillus casei CRL 431 used as a supplement in a repletion diet on the resistance to Streptococcus pneumoniae respiratory infection in malnourished mice. Weaned mice were malnourished after they consumed a protein-free diet (PFD) for 21 d. Malnourished mice were fed a balanced conventional diet (BCD) with or without supplemental L. casei for 7, 14, or 21 consecutive days, or BCD for 7 d with L. casei supplementation on d 6 and 7 (7dBCD+2dLc). The malnourished control (MNC) group was fed only the PFD, whereas well-nourished control (WNC) mice consumed the BCD ad libitum. Mice were challenged with S. pneumoniae at the end of each dietary treatment. Lung colonization and bacteremia were significantly greater in MNC than in WNC. Normalization of the immune response occurred in malnourished mice fed the BCD for 21 d. L. casei supplementation reduced the time required for a normal response from 21 to 7 d. Mice administered the 7dBCD+2dLc repletion treatment had a more effective pathogen clearance from blood and significantly lower lung damage than MNC. This treatment improved both the number of leukocytes and neutrophils in blood and bronchoalveolar lavages (BAL) and the bactericidal function of phagocytic cells to levels that did not differ from those of WNC. In the 7dBCD+2dLc mice, antipneumococcal IgA in BAL was higher than in WNC, whereas antipneumococcal IgG in serum and BAL did not differ. This study suggests that the addition of L. casei to the repletion diet has a beneficial effect because it accelerates the recovery of the innate immune response and improves the specific immune mechanisms against an S. pneumoniae respiratory infection in malnourished mice.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lacticaseibacillus caseiElevated Antipneumococcal IgA Levels in Bronchoalveolar Lavage FluidBeneficial
Moderate
Lacticaseibacillus caseiImproved Immune Mechanisms Against S. pneumoniaeBeneficial
Large
Lacticaseibacillus caseiImproved Immune ResponseBeneficial
Large
Lacticaseibacillus caseiImproved Pathogen ClearanceBeneficial
Large
Lacticaseibacillus casei R0215Elevated Antipneumococcal IgA Levels in Bronchoalveolar Lavage FluidBeneficial
Moderate
Lacticaseibacillus casei R0215Improved Resistance to Pneumococcal Respiratory InfectionBeneficial
Large
Lactobacillus caseiEnhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus caseiEnhanced Immune ResponseBeneficial
Large
Lactobacillus caseiImproved Bactericidal Function of Phagocytic CellsBeneficial
Moderate
Lactobacillus caseiImproved Pathogen ClearanceBeneficial
Large
Lactobacillus casei HA-108Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei HA-108Improved Innate Immune ResponseBeneficial
Large
Lactobacillus casei HA-108Improved Pathogen ClearanceBeneficial
Large
Lactobacillus casei LC03Improved Immune Cell FunctionBeneficial
Large
Lactobacillus casei LC03Improved Pathogen Clearance from BloodBeneficial
Large
Lactobacillus casei LC03Improved Respiratory Infection ResistanceBeneficial
Large
Lactobacillus casei LC03Increased Serum Immunoglobulin A (IgA) LevelsBeneficial
Moderate
Lactobacillus casei Lc-11Elevated Antipneumococcal IgA Levels in Bronchoalveolar Lavage FluidBeneficial
Moderate
Lactobacillus casei Lc-11Improved Immune ResponseBeneficial
Large
Lactobacillus casei Lc-11Improved Pathogen ClearanceBeneficial
Large
Lactobacillus casei PXN 37Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei PXN 37Enhanced Resistance to Streptococcus Pneumoniae InfectionBeneficial
Large
Lactobacillus casei PXN 37Improved Immune Cell CountsBeneficial
Large
Lactobacillus casei PXN 37Improved Pathogen ClearanceBeneficial
Large
Lactobacillus casei R0215Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei R0215Improved Bactericidal Function of Phagocytic CellsBeneficial
Moderate
Lactobacillus casei R0215Improved Immune ResponseBeneficial
Large
Lactobacillus casei SD-5213Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei SD-5213Improved Respiratory Infection ResistanceBeneficial
Large
Lactobacillus casei SD5213Accelerated Innate Immune Response RecoveryBeneficial
Large
Lactobacillus casei SD5213Improved Pathogen ClearanceBeneficial
Large
Lactobacillus casei SD-5842Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei SD-5842Improved Bactericidal Function of Phagocytic CellsBeneficial
Moderate
Lactobacillus casei SD-5842Improved Resistance to Pneumococcal InfectionBeneficial
Large
Lactobacillus casei subsp. caseiImproved Immune Cell FunctionBeneficial
Large
Lactobacillus casei subsp. caseiImproved Pathogen ClearanceBeneficial
Large
Lactobacillus casei subsp. caseiImproved Respiratory Infection ResistanceBeneficial
Large
Lactobacillus casei subsp. caseiIncreased Serum Immunoglobulin A (IgA) LevelsBeneficial
Moderate
Lactobacillus casei UALc-03Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus casei UALc-03Improved Bactericidal Function of Phagocytic CellsBeneficial
Moderate
Lactobacillus casei UALc-03Improved Immune Mechanisms Against S. pneumoniaeBeneficial
Large
Lactobacillus casei UALc-03Improved Innate Immune ResponseBeneficial
Large
Lactobacillus casei UALc-03Improved Resistance to Pneumococcal Respiratory InfectionBeneficial
Large
Lactobacillus casei VK4Enhanced Antipneumococcal IgA Levels in BALBeneficial
Moderate
Lactobacillus genseniImproved Immune Cell FunctionBeneficial
Large
Lactobacillus genseniImproved Respiratory Infection ResistanceBeneficial
Large
Lactobacillus genseniIncreased Serum Immunoglobulin A (IgA) LevelsBeneficial
Moderate
Lactobacillus genseniReduced Lung DamageBeneficial
Large
Lactobacillus paracasei 431Improved Immune Cell FunctionBeneficial
Large
Lactobacillus paracasei 431Improved Pathogen ClearanceBeneficial
Large
Lactobacillus paracasei 431Improved Respiratory Infection ResistanceBeneficial
Large
Lactobacillus paracasei 431Increased Serum Immunoglobulin A (IgA) LevelsBeneficial
Moderate
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