Lactobacillus crispatus represses vaginolysin expression by BV associated Gardnerella vaginalis and reduces cell cytotoxicity.
- 2018-04
- Anaerobe 50
- J. Castro
- A. Martins
- M. E. Rodrigues
- N. Cerca
- PubMed: 29427630
- DOI: 10.1016/j.anaerobe.2018.01.014
Abstract
Using a chemically-defined medium simulating genital tract secretions, we have shown that pre-adhering Lactobacillus crispatus to Hela epithelial cells reduced cytotoxicity caused by Gardnerella vaginalis. This effect was associated to the expression of vaginolysin and was specific to L. crispatus interference, as other vaginal facultative anaerobes had no protective effect.
Keywords: Bacterial vaginosis; G. vaginalis; L. crispatus; Sialidase; Vaginolysin.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactobacillus crispatus LBV 88 | Reduced Cytotoxicity | Beneficial | Moderate |
| Lactobacillus crispatus LBV88 | Reduced Cytotoxicity | Beneficial | Moderate |
| Lactobacillus crispatus LCr86 | Reduced Cytotoxicity | Beneficial | Moderate |
| Lactobacillus crispatus LV5 88 | Reduced Cytotoxicity | Beneficial | Moderate |
| Lactobacillus crispatus UALcr-35 | Reduced Cytotoxicity Induced by Gardnerella Vaginalis | Beneficial | Moderate |
| Lactobacillus crispatus VPro 31 | Reduced Cytotoxicity | Beneficial | Moderate |