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Abstract

Using a chemically-defined medium simulating genital tract secretions, we have shown that pre-adhering Lactobacillus crispatus to Hela epithelial cells reduced cytotoxicity caused by Gardnerella vaginalis. This effect was associated to the expression of vaginolysin and was specific to L. crispatus interference, as other vaginal facultative anaerobes had no protective effect.

Keywords: Bacterial vaginosis; G. vaginalis; L. crispatus; Sialidase; Vaginolysin.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus crispatus LBV 88Reduced CytotoxicityBeneficial
Moderate
Lactobacillus crispatus LBV88Reduced CytotoxicityBeneficial
Moderate
Lactobacillus crispatus LCr86Reduced CytotoxicityBeneficial
Moderate
Lactobacillus crispatus LV5 88Reduced CytotoxicityBeneficial
Moderate
Lactobacillus crispatus UALcr-35Reduced Cytotoxicity Induced by Gardnerella VaginalisBeneficial
Moderate
Lactobacillus crispatus VPro 31Reduced CytotoxicityBeneficial
Moderate
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