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Abstract

This study aimed to determine the effects of a Lactobacillus helveticus-fermented milk drink containing lactononadecapeptide (NIPPLTQTPVVVPPFLQPE) on the cognitive function of healthy middle-aged adults. A randomised, double-blind controlled study was conducted in healthy participants who were randomly assigned to receive a L. helveticus-fermented milk drink (190 g/day) or the equivalent amount of a placebo drink once a day for eight weeks. Cognitive function was evaluated using the Japanese version of the repeatable battery for the assessment of neuropsychological status (RBANS) test. There was a statistically significant improvement in the total score, attention score, and delayed memory score of participants who received the L. helveticus-fermented milk drink. There was also a significant difference in the attention score between the placebo and test groups after eight weeks (p = .028). Therefore, supplementation of healthy middle-aged adults with a L. helveticus-fermented milk drink for eight weeks improved both attention and delayed memory.

Keywords: Attention; Lactobacillus helveticus; cognitive function; lactononadecapeptide; memory.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticusImproved Attention SpanBeneficial
Moderate
Lactobacillus helveticusImproved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticusImproved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus HA-128Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus HA-128Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus HA-128Improved Memory FunctionBeneficial
Moderate
Lactobacillus helveticus HA-501Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus HA-501Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus HA-501Improved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus L10Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus L10Improved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus LH76Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus LH76Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus LH76Improved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus R0052Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus R0052Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52Improved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEImproved Attention SpanBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEImproved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEImproved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Attention SpanBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Cognitive FunctionBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDImproved Delayed MemoryBeneficial
Moderate
Lactobacillus helveticus VPro 13Improved Attention SpanBeneficial
Moderate
Lactobacillus helveticus VPro 13Improved Cognitive FunctionBeneficial
Moderate
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