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Lactobacillus helveticus KLDS1.8701 alleviates d-galactose-induced aging by regulating Nrf-2 and gut microbiota in mice.

  • 2018
  • Food & Function 9(12)
    • Bailiang Li
    • S. Evivie
    • Jingjing Lu
    • Y. Jiao
    • Chengfeng Wang
    • Ziye Li
    • Fei Liu
    • G. Huo

Abstract

Aging is commonly associated with chronic oxidative stress and mild inflammation that can cause a variety of degenerative diseases. Lactic acid bacteria (LAB) provide several health benefits to the host including antioxidant activity and immune system regulation. However, there is a lack of information regarding the antioxidant mechanisms of probiotics in vivo. Therefore, the aim of this study was to elucidate the possible mechanisms for the preventive effect of LAB on aging. First, 25 LAB strains were screened for finding potential probiotics with high antioxidant capacity using in vitro methods. Second, d-galactose was administered by subcutaneous injection once daily for 8 weeks to establish an aging mouse model to investigate the protective effects and underlying mechanisms of the potential probiotic strain Lactobacillus helveticus KLDS1.8701, identified from the screening. The results in vitro showed that L. helveticus KLDS1.8701 had a better property with remarkable free radical scavenging activity. In vivo, L. helveticus KLDS1.8701 supplementation significantly ameliorated aging-related changes such as decreased organic index, liver injury and increased endotoxin. L. helveticus KLDS1.8701 supplementation reduced hepatic oxidative stress by modulating the Nrf-2 pathway. Notably, L. helveticus KLDS1.8701 supplementation restored the gut microbiota composition to that of the control group, resulting in increased butyrate production and decreased endotoxin production. These findings indicated that L. helveticus KLDS1.8701 supplementation manipulated gut microbiota and its metabolites could attenuate hepatic oxidative stress via the gut-liver axis.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactobacillus helveticusImproved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticusReduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticusRestored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus HA-128Improved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus HA-128Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus HA-128Restored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus L10Improved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus L10Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus L10Restored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus LH76Improved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus LH76Improved Free Radical Scavenging ActivityBeneficial
Moderate
Lactobacillus helveticus LH76Improved Gut Microbiome CompositionBeneficial
Large
Lactobacillus helveticus LH76Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus R0052Improved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus R0052Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus R0052Restored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus Rosell-52Improved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus Rosell-52Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus Rosell-52Restored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus Rosell-52 MEImproved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus Rosell-52 MEReduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus Rosell-52 MERestored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus Rosell-52NDImproved Aging-Related ChangesBeneficial
Moderate
Lactobacillus helveticus Rosell-52NDReduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus Rosell-52NDRestored Gut Microbiota CompositionBeneficial
Large
Lactobacillus helveticus VPro 13Reduced Aging-related ChangesBeneficial
Large
Lactobacillus helveticus VPro 13Reduced Hepatic Oxidative StressBeneficial
Large
Lactobacillus helveticus VPro 13Restored Gut Microbiota CompositionBeneficial
Large
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