Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice
- 2016-04-07
- Nutrients 8(4)
- Yi-Ming Chen
- Li Wei
- Yen-Shuo Chiu
- Y. Hsu
- Tsung-Yu Tsai
- Ming-Fu Wang
- Chi-Chang Huang
- PubMed: 27070637
- DOI: 10.3390/nu8040205
Abstract
Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 × 10⁸, or 1.03 × 10⁹ colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.
Keywords: Lactobacillus plantarum TWK10; exercise performance; forelimb grip strength; gastrocnemius muscles.
Research Insights
| Supplement | Health Outcome | Effect Type | Effect Size |
|---|---|---|---|
| Lactiplantibacillus plantarum LP-1 | Improved Grip Strength | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Increased Endurance Swimming Time | Beneficial | Moderate |
| Lactiplantibacillus plantarum LP-1 | Increased Muscle Mass | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Increased Type I Muscle Fiber Count | Beneficial | Moderate |
| Lactiplantibacillus plantarum LP-1 | Reduced Blood Urea Nitrogen Levels | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Reduced Body Weight | Beneficial | Moderate |
| Lactiplantibacillus plantarum LP-1 | Reduced Glucose Levels | Beneficial | Small |
| Lactiplantibacillus plantarum LP-1 | Reduced Lactate Levels | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Reduced Serum Albumin Levels | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Reduced Serum Ammonia Levels | Beneficial | Large |
| Lactiplantibacillus plantarum LP-1 | Reduced Serum Creatine Kinase Levels | Beneficial | Moderate |
| Lactiplantibacillus plantarum LP-1 | Reduced Serum Triacylglycerols | Beneficial | Moderate |
| Lactobacillus plantarum | Improved Muscle Composition | Beneficial | Large |
| Lactobacillus plantarum | Improved Muscle Endurance | Beneficial | Large |
| Lactobacillus plantarum | Improved Muscle Strength | Beneficial | Large |
| Lactobacillus plantarum | Improved Weight Management | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Blood Urea Nitrogen Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced Creatine Kinase Levels | Beneficial | Moderate |
| Lactobacillus plantarum | Reduced Exercise-Induced Ammonia Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced Exercise-Induced Glucose Levels | Beneficial | Small |
| Lactobacillus plantarum | Reduced Post-Exercise Lactate Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced Serum Albumin Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced Serum Creatinine Levels | Beneficial | Large |
| Lactobacillus plantarum | Reduced Triglyceride Levels | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Improved Exercise Performance | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Improved Metabolic Profile | Beneficial | Moderate |
| Lactobacillus plantarum LP-01 | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum LP-01 | Reduced Physical Fatigue | Beneficial | Large |
| Lactobacillus plantarum LP09 | Improved Exercise Performance | Beneficial | Large |
| Lactobacillus plantarum LP09 | Improved Metabolic Health | Beneficial | Moderate |
| Lactobacillus plantarum LP09 | Improved Muscle Composition | Beneficial | Large |
| Lactobacillus plantarum LP09 | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum LP09 | Reduced Physical Fatigue | Beneficial | Large |
| Lactobacillus plantarum R1012 | Improved Endurance | Beneficial | Large |
| Lactobacillus plantarum R1012 | Improved Grip Strength | Beneficial | Large |
| Lactobacillus plantarum R1012 | Improved Muscle Composition | Beneficial | Large |
| Lactobacillus plantarum R1012 | Improved Serum Biomarkers | Beneficial | Moderate |
| Lactobacillus plantarum R1012 | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum R1012 | Reduced Physical Fatigue | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Improved Exercise Performance | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Improved Health Markers | Beneficial | Moderate |
| Lactobacillus plantarum Rosell-A | Improved Muscle Composition | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum Rosell-A | Reduced Physical Fatigue | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Enhanced Slow Muscle Fiber Development | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Improved Endurance | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Improved Energy Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Improved Grip Strength | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Blood Urea Nitrogen Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Creatine Kinase Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Serum Albumin Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Serum Ammonia Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Serum Creatinine Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Serum Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum SD5209 | Reduced Serum Lactate Levels | Beneficial | Large |
| Lactobacillus plantarum SD5209 | Reduced Triglyceride Levels | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Improved Energy Levels | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Improved Exercise Performance | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Improved Metabolic Health | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum UALp-05M | Increased Type I Muscle Fiber Count | Beneficial | Moderate |
| Lactobacillus plantarum UALp-05M | Reduced Physical Fatigue | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Improved Endurance | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Improved Energy Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Improved Grip Strength | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Increased Muscle Mass | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Increased Type I Muscle Fiber Count | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Ammonia Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced Blood Glucose Levels | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Blood Urea Nitrogen Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced Body Weight | Beneficial | Moderate |
| Lactobacillus plantarum VPro 10 | Reduced Fatigue | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced Serum Albumin Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced Serum Lactate Levels | Beneficial | Large |
| Lactobacillus plantarum VPro 10 | Reduced Serum Triacylglycerols | Beneficial | Moderate |