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Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice

  • 2016-04-07
  • Nutrients 8(4)
    • Yi-Ming Chen
    • Li Wei
    • Yen-Shuo Chiu
    • Y. Hsu
    • Tsung-Yu Tsai
    • Ming-Fu Wang
    • Chi-Chang Huang

Abstract

Lactobacillus plantarum (L. plantarum) is a well-known probiotic among the ingested-microorganism probiotics (i.e., ingested microorganisms associated with beneficial effects for the host). However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n = 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 × 10⁸, or 1.03 × 10⁹ colony-forming units/kg/day, designated the vehicle, LP10-1X and LP10-5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight (%). LP10 supplementation dose-dependently increased grip strength (p < 0.0001) and endurance swimming time (p < 0.001) and decreased levels of serum lactate (p < 0.0001), ammonia (p < 0.0001), creatine kinase (p = 0.0118), and glucose (p = 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long-term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health-promotion, performance-improvement, and anti-fatigue effects.

Keywords: Lactobacillus plantarum TWK10; exercise performance; forelimb grip strength; gastrocnemius muscles.

Research Insights

SupplementHealth OutcomeEffect TypeEffect Size
Lactiplantibacillus plantarum LP-1Improved Grip StrengthBeneficial
Large
Lactiplantibacillus plantarum LP-1Increased Endurance Swimming TimeBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Increased Muscle MassBeneficial
Large
Lactiplantibacillus plantarum LP-1Increased Type I Muscle Fiber CountBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Blood Urea Nitrogen LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Body WeightBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Glucose LevelsBeneficial
Small
Lactiplantibacillus plantarum LP-1Reduced Lactate LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Serum Albumin LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Serum Ammonia LevelsBeneficial
Large
Lactiplantibacillus plantarum LP-1Reduced Serum Creatine Kinase LevelsBeneficial
Moderate
Lactiplantibacillus plantarum LP-1Reduced Serum TriacylglycerolsBeneficial
Moderate
Lactobacillus plantarumImproved Muscle CompositionBeneficial
Large
Lactobacillus plantarumImproved Muscle EnduranceBeneficial
Large
Lactobacillus plantarumImproved Muscle StrengthBeneficial
Large
Lactobacillus plantarumImproved Weight ManagementBeneficial
Moderate
Lactobacillus plantarumReduced Blood Urea Nitrogen LevelsBeneficial
Large
Lactobacillus plantarumReduced Creatine Kinase LevelsBeneficial
Moderate
Lactobacillus plantarumReduced Exercise-Induced Ammonia LevelsBeneficial
Large
Lactobacillus plantarumReduced Exercise-Induced Glucose LevelsBeneficial
Small
Lactobacillus plantarumReduced Post-Exercise Lactate LevelsBeneficial
Large
Lactobacillus plantarumReduced Serum Albumin LevelsBeneficial
Large
Lactobacillus plantarumReduced Serum Creatinine LevelsBeneficial
Large
Lactobacillus plantarumReduced Triglyceride LevelsBeneficial
Large
Lactobacillus plantarum LP-01Improved Exercise PerformanceBeneficial
Large
Lactobacillus plantarum LP-01Improved Metabolic ProfileBeneficial
Moderate
Lactobacillus plantarum LP-01Increased Muscle MassBeneficial
Large
Lactobacillus plantarum LP-01Reduced Physical FatigueBeneficial
Large
Lactobacillus plantarum LP09Improved Exercise PerformanceBeneficial
Large
Lactobacillus plantarum LP09Improved Metabolic HealthBeneficial
Moderate
Lactobacillus plantarum LP09Improved Muscle CompositionBeneficial
Large
Lactobacillus plantarum LP09Increased Muscle MassBeneficial
Large
Lactobacillus plantarum LP09Reduced Physical FatigueBeneficial
Large
Lactobacillus plantarum R1012Improved EnduranceBeneficial
Large
Lactobacillus plantarum R1012Improved Grip StrengthBeneficial
Large
Lactobacillus plantarum R1012Improved Muscle CompositionBeneficial
Large
Lactobacillus plantarum R1012Improved Serum BiomarkersBeneficial
Moderate
Lactobacillus plantarum R1012Increased Muscle MassBeneficial
Large
Lactobacillus plantarum R1012Reduced Physical FatigueBeneficial
Large
Lactobacillus plantarum Rosell-AImproved Exercise PerformanceBeneficial
Large
Lactobacillus plantarum Rosell-AImproved Health MarkersBeneficial
Moderate
Lactobacillus plantarum Rosell-AImproved Muscle CompositionBeneficial
Large
Lactobacillus plantarum Rosell-AIncreased Muscle MassBeneficial
Large
Lactobacillus plantarum Rosell-AReduced Physical FatigueBeneficial
Large
Lactobacillus plantarum SD5209Enhanced Slow Muscle Fiber DevelopmentBeneficial
Large
Lactobacillus plantarum SD5209Improved EnduranceBeneficial
Large
Lactobacillus plantarum SD5209Improved Energy LevelsBeneficial
Large
Lactobacillus plantarum SD5209Improved Grip StrengthBeneficial
Large
Lactobacillus plantarum SD5209Increased Muscle MassBeneficial
Large
Lactobacillus plantarum SD5209Reduced Blood Urea Nitrogen LevelsBeneficial
Large
Lactobacillus plantarum SD5209Reduced Creatine Kinase LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Serum Albumin LevelsBeneficial
Large
Lactobacillus plantarum SD5209Reduced Serum Ammonia LevelsBeneficial
Large
Lactobacillus plantarum SD5209Reduced Serum Creatinine LevelsBeneficial
Large
Lactobacillus plantarum SD5209Reduced Serum Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum SD5209Reduced Serum Lactate LevelsBeneficial
Large
Lactobacillus plantarum SD5209Reduced Triglyceride LevelsBeneficial
Large
Lactobacillus plantarum UALp-05MImproved Energy LevelsBeneficial
Large
Lactobacillus plantarum UALp-05MImproved Exercise PerformanceBeneficial
Large
Lactobacillus plantarum UALp-05MImproved Metabolic HealthBeneficial
Moderate
Lactobacillus plantarum UALp-05MIncreased Muscle MassBeneficial
Large
Lactobacillus plantarum UALp-05MIncreased Type I Muscle Fiber CountBeneficial
Moderate
Lactobacillus plantarum UALp-05MReduced Physical FatigueBeneficial
Large
Lactobacillus plantarum VPro 10Improved EnduranceBeneficial
Large
Lactobacillus plantarum VPro 10Improved Energy LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Improved Grip StrengthBeneficial
Large
Lactobacillus plantarum VPro 10Increased Muscle MassBeneficial
Large
Lactobacillus plantarum VPro 10Increased Type I Muscle Fiber CountBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Ammonia LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Blood Glucose LevelsBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced Blood Urea Nitrogen LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Body WeightBeneficial
Moderate
Lactobacillus plantarum VPro 10Reduced FatigueBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Serum Albumin LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Serum Lactate LevelsBeneficial
Large
Lactobacillus plantarum VPro 10Reduced Serum TriacylglycerolsBeneficial
Moderate
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